Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer
Xiaoqian Yang,Arun K. Iyer,Arun K. Iyer,Amit Singh,Lara Milane,Edwin Choy,Francis J. Hornicek,Mansoor M. Amiji,Zhenfeng Duan +8 more
TLDR
These findings suggest that this CD44 targeted HA-PEI/HA-PEG nanoparticle platform may be a clinicaly relevant gene delivery system for systemic siRNA-based anticancer therapeutics for the treatment of MDR cancers.Abstract:
Purpose
Approaches for the synthesis of biomaterials to facilitate the delivery of “biologics” is a major area of research in cancer therapy. Here we designed and characterized a hyaluronic acid (HA) based self-assembling nanoparticles that can target CD44 receptors overexpressed on multidrug resistance (MDR) ovarian cancer. The nanoparticle system is composed of HA-poly(ethyleneimine)/HA-poly(ethylene glycol) (HA-PEI/HA-PEG) designed to deliver MDR1 siRNA for the treatment of MDR in an ovarian cancer model.read more
Citations
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Journal ArticleDOI
Hyaluronic acid for anticancer drug and nucleic acid delivery.
TL;DR: The rationale underlying approaches, chemical strategies, and recent advances in the use of HA to design drug carriers for delivering anticancer agents, are reviewed and descriptions are given of HA-based drug conjugates, particulate carriers, inorganic nanostructures, and hydrogels.
Journal ArticleDOI
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
TL;DR: This review of CD44 receptor biology and its involvement in the different stages of tumor growth and metastasis, as well as methods currently used for targeting the receptor, outlines a number of research approaches from the current literature that take advantage of hyaluronic acid’s targeting ability.
Journal ArticleDOI
Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
Nirmala Chandralega Kampan,Mutsa Tatenda Madondo,Orla McNally,Michael A. Quinn,Magdalena Plebanski +4 more
TL;DR: Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management, but newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.
Journal ArticleDOI
Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system.
Gangliang Huang,Hualiang Huang +1 more
TL;DR: Hyaluronic acid is a natural polysaccharide with good biocompatibility and degradability and can be used for targeted drug delivery, especially for the delivery of anti‐tumor drugs.
Journal ArticleDOI
The Role of CD44 in Disease Pathophysiology and Targeted Treatment
TL;DR: This review focuses both CD44-hyaluronan dependent and independent CD44 signaling and the role of CD44–HA interaction in various pathophysiologies and the recent advances in novel treatment strategies that exploit the CD44 –HA interaction either for direct targeting or for drug delivery.
References
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Journal ArticleDOI
Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Journal ArticleDOI
Mechanisms of cancer drug resistance
TL;DR: The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance as mentioned in this paper.
Journal ArticleDOI
Delivery materials for siRNA therapeutics
TL;DR: An introduction to the biological challenges that siRNA delivery materials aim to overcome is provided, as well as a discussion of the way that the most effective and clinically advanced classes of si RNA delivery systems are designed to surmount these challenges.
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The biology of ovarian cancer: new opportunities for translation
TL;DR: Increase in long-term survival in ovarian cancer patients might be achieved by translating recent insights at the molecular and cellular levels to personalize individual strategies for treatment and to optimize early detection.