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Coeliac Disease
G. K. T. Holmes,W. T. Cooke +1 more
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The article was published on 1984-04-01 and is currently open access. It has received 2747 citations till now. The article focuses on the topics: Anti-transglutaminase antibodies & HLA-DQ2.read more
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Journal ArticleDOI
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease
Steffen Husby,Sibylle Koletzko,Alan D. Phillips,Raanan Shamir,Riccardo Troncone,Klaus Giersiepen,D. Branski,Carlo Catassi,M. Lelgeman,Carmen Ribes-Koninckx,Alessandro Ventura +10 more
TL;DR: The aim of the new guidelines for coeliac disease was to achieve a high diagnostic accuracy and to reduce the burden for patients and their families.
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Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’)
TL;DR: The nature and basis of nonresponsive celiac sprue require more thoughtful initiatives to elucidate the immunologic mechanism(s) of unresponsiveness and evaluate possible means of reversal.
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Structural Basis for Gluten Intolerance in Celiac Sprue
Lu Shan,Øyvind Molberg,Isabelle Parrot,Felix Hausch,Ferda Filiz,Gary M. Gray,Ludvig M. Sollid,Chaitan Khosla +7 more
TL;DR: A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients, and could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for CeliacSprue.
Journal ArticleDOI
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease
TL;DR: Given the incomplete response of many patients to a GFD-free diet as well as the difficulty of adherence to the GFD over the long term, development of new effective therapies for symptom control and reversal of inflammation and organ damage are needed.
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Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum☆
Alessio Fasano,Carlo Catassi +1 more
TL;DR: The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided.