Journal ArticleDOI
Combined Cancer Chemo-Photodynamic and Photothermal Therapy Based on ICG/PDA/TPZ-Loaded Nanoparticles
Huang Xiaqin,Junru Wu,Muye He,Xinyu Hou,Yan Wang,Xiaoran Cai,Hongliang Xin,Feng Gao,Yanzuo Chen +8 more
Reads0
Chats0
TLDR
It is demonstrated that ICG-PDA-TPZ NPs showed intensive photodynamic and photothermal effects in vitro and in vivo, which synergized with TPZ in subcutaneous U87 malignant glioma growth and orthotopic B16F10 tumor inhibition, with negligible side effects.Abstract:
Although photodynamic therapy (PDT) has been an attractive strategy for several cancer treatments in the clinical setting, PDT efficacy is attenuated by consumption of oxygen. To address this photodynamic issue, we adopted a phototherapy-chemotherapy combination strategy based on targeted delivery of the near-infrared photosensitizer indocyanine green (ICG), photothermal conversion agent polydopamine (PDA), and tirapazamine (TPZ), a hypoxia-activated prodrug. Under laser irradiation, ICG consumption of oxygen and aggravated hypoxia in tumor sites can activate TPZ to damage DNA. In parallel, ICG produces reactive oxygen species which work in synergy with PDA to enhance phototherapeutic efficiency. Herein, hybrid CaCO3/TPGS nanoparticles delivering ICG, PDA, and TPZ (ICG-PDA-TPZ NPs) were designed for effective and safe cancer therapy. ICG-PDA-TPZ NPs showed significantly improved cellular uptake and accumulation in tumors. Furthermore, we demonstrated that ICG-PDA-TPZ NPs showed intensive photodynamic and photothermal effects in vitro and in vivo, which synergized with TPZ in subcutaneous U87 malignant glioma growth and orthotopic B16F10 tumor inhibition, with negligible side effects. Thus, ICG-PDA-TPZ NPs could be an effective strategy for improvement of PDT.read more
Citations
More filters
Journal ArticleDOI
Photodynamic therapy for hypoxic tumors: Advances and perspectives
Li Huang,Shaojing Zhao,Jiasheng Wu,Le Yu,Nem Singh,Ke Yang,Minhuan Lan,Pengfei Wang,Jong Seung Kim +8 more
TL;DR: This tutorial review summarizes the strategies for improving the efficacy of PDT in hypoxic tumor therapy, and demonstrates the advantages of combining PDT with other therapeutics, such as chemotherapy, chemo-dynamic therapy, gas therapy, immunotherapy and gene therapy.
Journal ArticleDOI
Photodynamic Therapy for the Treatment of Glioblastoma
Samuel W. Cramer,Clark C. Chen +1 more
TL;DR: The FDA approval of 5-aminolevulinic acid for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT), and the general principles of PDT are reviewed.
Journal ArticleDOI
Engineering of a dual-modal phototherapeutic nanoplatform for single NIR laser-triggered tumor therapy.
TL;DR: In this article, a dual-modal phototherapeutic nanoplatform that achieved both photodynamic therapy (PDT) and photothermal therapy (PTT) under single NIR laser (660-nm) irradiation for chlorin e6 (Ce6) and copper sulfide (CuS) nanoparticles (NPs) is presented.
Journal ArticleDOI
Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy.
TL;DR: In this paper, the authors review the extensive application of thermosensitive hydrogel in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo/immuno- combined therapy.
Journal ArticleDOI
Recent advances in the development of near-infrared organic photothermal agents
TL;DR: In this review, the recent NIR absorbing organic PTTAs, such as several fixed structure N IR absorbing organic molecules with photothermal properties and donor-acceptor (D-A) type organic dyes for PTT applications, will be introduced and the potential development and present challenges will be discussed.
References
More filters
Journal ArticleDOI
Cancer statistics, 2018
TL;DR: The combined cancer death rate dropped continuously from 1991 to 2015 by a total of 26%, translating to approximately 2,378,600 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
Yanlan Liu,Kelong Ai,Lehui Lu +2 more
Journal ArticleDOI
Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy
TL;DR: Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.
Journal ArticleDOI
Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2 -Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.
TL;DR: A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment by relieving hypoxia.
Journal ArticleDOI
Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy.
Yuhao Cheng,Hao Cheng,Chenxiao Jiang,Xuefeng Qiu,Kaikai Wang,Wei Huan,Ahu Yuan,Jinhui Wu,Yiqiao Hu +8 more
TL;DR: Oxy-PDT is created by loading a photosensitizer into perfluorocarbon nanodroplets by demonstrated by the accelerated generation of 1O2 and elevated cytotoxicity and may enable the enhancement of existing clinical PDT and future PDT design.