Journal ArticleDOI
Common region on chromosome 14 in T-cell leukemia and lymphoma
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TLDR
It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function and Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T- cell malignancies.Abstract:
Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies.read more
Citations
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Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1
Mark Kowalski,Joseph Potz,Ladan Basiripour,Tatyana Dorfman,Wei Chun Goh,Ernest Terwilliger,Andrew Dayton,Craig A. Rosen,William A. Haseltine,Joseph Sodroski +9 more
TL;DR: These findings provide a functional model of the HIV envelope glycoprotein that can be divided into five groups: those that decrease the binding of the envelope protein to the CD4 molecule, those that prevent a post-binding fusion reaction, and those that disrupt the anchorage of the envelopes in the membrane.
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The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis
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Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
James A. Hoxie,James D. Alpers,Jerome L. Rackowski,Kay Huebner,Beth S. Haggarty,Andrew J. Cedarbaum,John C. Reed +6 more
TL;DR: The data suggested that the T4 protein produced after infection may be complexed with viral envelope gene products within infected cells, and may participate in a general mechanism by which receptors for retroviruses are down-modulated and alterations in cellular function develop after infection.
Book ChapterDOI
Activation of cellular oncogenes in hemopoietic cells by chromosome translocation.
TL;DR: The recent localization of the metallothionein gene cluster to the band q22 of chromosome 16 raises intriguing questions regarding the chromosome abnormalities associated with acute myelomonocytic leukemia (AMML).
Journal ArticleDOI
lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
TL;DR: A transcription unit at chromosome band 19p13 that lies at the site of a chromosomal translocation breakpoint in T cell acute lymphoblastic leukemia is characterized, suggesting that other proteins containing similar DNA binding motifs may also be involved with neoplastic transformation in various cellular lineages.
References
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Journal ArticleDOI
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
Rebecca Taub,Ilan R. Kirsch,Cynthia C. Morton,Gilbert M. Lenoir,D. Swan,Steven R. Tronick,Stuart A. Aaronson,Philip Leder +7 more
TL;DR: It is shown that transformation of human Burkitt lymphomas and murine plasmacytomas is frequently accompanied by the somatic rearrangement of a cellular analogue of an avian retrovirus transforming gene, c-myc, which provides a molecular basis for considering the role that specific translocations might play in malignant transformation.
Journal ArticleDOI
The Chromosomal Basis of Human Neoplasia
TL;DR: It is proposed that chromosomal rearrangements play a central role in human neoplasia and may exert their effects through related genomic mechanisms and a translocation could serve to place an oncogene next to an activating DNA sequence, a deletion to eliminate anOncogene repressor, and trisomy to carry extra gene dosage.
Journal ArticleDOI
Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomas
TL;DR: The karyotypes of cells from 10 Burkitt lymphoma biopsies, eight cell lines established from BL and nine cell lines from non‐BL sources were studied by chromosome banding techniques and it is suggested that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q‐; 14q+).
Journal ArticleDOI
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.
Stanley J. Korsmeyer,Andrew Arnold,Ajay Bakhshi,Jeffrey V. Ravetch,Ulrich Siebenlist,Philip Hieter,Susan O. Sharrow,Tucker W. LeBien,J. H. Kersey,David G. Poplack,Philip Leder,Thomas A. Waldmann +11 more
TL;DR: Correlations here suggest that cells entering B cell development express HLA-DR and rearrange heavy chain genes before the expression of a B cell-associated antigen recognized by the antibody BA-1, the antigen CALLA, and any subsequent light chain gene rearrangements.
Journal ArticleDOI
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma
TL;DR: The studies indicate that detection of immunoglobulin gene rearrangements is a valuable method for diagnosis and classification of various lymphoproliferative disorders that are difficult to evaluate histologically or that lack distinctive antigenic markers.