Journal ArticleDOI
Comparison of clastogenic effects of antimony and bismuth as trioxides on mice in vivo
TLDR
Comparison of theClastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter.Abstract:
Comparison of the clastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter. Three doses of each chemical (400, 666.67, and 1000 mg/kg body wt), corresponding to 1/50, 1/30, and 1/20 of oral LD50 of antimony trioxide, were fed daily to sets of mice up to 21 d. Animals were sacrificed on day 7, 14, and 21 of the experiment. Chromosomal aberrations and mitotic index were studied from bone marrow cells following a colchicine-air drying Giemsa schedule. The frequencies of chromosomal aberrations induced by both chemicals were directly proportional to the dose used and the duration of exposure, indicating their cumulative effects on the organism. The highest dose of antimony, given for the longest period was, however, lethal. Effects on germ cells, as shown by screening for sperm head abnormalities, were not significant.read more
Citations
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Journal ArticleDOI
Arsenic and antimony: comparative approach on mechanistic toxicology
TL;DR: There is evidence that in mammals antimony, unlike arsenic, is not detoxified via methylation but it still remains unclear what mechanism is responsible for antimony's genotoxicity.
Journal ArticleDOI
Cobalt and antimony: genotoxicity and carcinogenicity.
TL;DR: Given the recently provided proof for in vitro and in vivo genotoxic potential of hard metal dust, the mechanistic evidence of elevated production of active oxygen species and the epidemiological data on increased cancer risk, it may be advisable to consider the possibility of a new evaluation by IARC.
Journal ArticleDOI
Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds
TL;DR: An overview about the environmental distribution of organometal(loid) compounds and the potential hazardous effects on animal and human health is given.
Journal ArticleDOI
Genotoxic risk and oxidative DNA damage in workers exposed to antimony trioxide.
Delia Cavallo,Ivo Iavicoli,Andrea Setini,Alessandro Marinaccio,Barbara Perniconi,Giovanni Carelli,Sergio Iavicoli +6 more
TL;DR: The results support the theory that oxidative DNA damage is involved in the genotoxicity of antimony and indicate the need for further research in this field.
Journal ArticleDOI
Antimony and its compounds: Health impacts related to pulmonary toxicity, cancer, and genotoxicity.
Craig J. Boreiko,Toby G. Rossman +1 more
TL;DR: Although occupational exposure to antimony and its compounds can produce pulmonary toxicity, human carcinogenic impacts have not been observed, and inhalation studies with respirable antimony trioxide particles administered to rats and mice have induced carcinogenic responses in the lungs and related tissue sites.
References
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Book
Statistical Tables for Biological, Agricultural and Medical Research
R. A. Fisher,Frank Yates +1 more
TL;DR: Sir Ronald A. Fisher and Frank Yates: Statistical Tables for Biological, Agricultural and Medical Research.
Journal ArticleDOI
Chemical induction of sperm abnormalities in mice.
Andrew J. Wyrobek,W R Bruce +1 more
TL;DR: The results suggest that sperm abnormalities might provide a rapid inexpensive mammalian screen for agents that lead to errors in the differentiation of spermatogenic stem cells in vivo and thus indicate agents which might prove to be mutagenic, teratogenic, or carcinogenic.
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The probability integrals of the range and of the studentized range. probability integral and percentage points of the studentized range; critical values for duncan's new multiple range test
TL;DR: In this article, the authors report critical values (to four significant figures) which have been found by inverse interpolation in the new table of the probability integral of the studentized range.
Journal ArticleDOI
Critical values for duncan's new multiple range test
TL;DR: In this paper, the authors report critical values (to four significant figures) which have been found by inverse interpolation in the new table of the probability integral of the studentized range.