Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA
Mutsunori Shirai,Hideki Hirakawa,Mitsuaki Kimoto,Mitsuaki Tabuchi,Fumio Kishi,Kazunobu Ouchi,Tadayoshi Shiba,Kazuo Ishii,Masahira Hattori,Satoru Kuhara,Teruko Nakazawa +10 more
TLDR
The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates.Abstract:
Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C.PNEUMONIAE: infection and atherosclerosis. We determined the whole genome sequence of C.PNEUMONIAE: strain J138 isolated in Japan in 1994 and compared it with the sequence of strain CWL029 isolated in the USA before 1987. The J138 circular chromosome consists of 1 226 565 nt (40.7% G+C) with 1072 likely protein-coding genes that is 3665 nt shorter than the CWL029 genome. Plasmids, phage- or transposon-like sequences were not identified. The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates. The most conspicuous differences in the J138 genome relative to the CWL029 genome are the absence of five DNA segments, ranging in size from 89 to 1649 nt, and the presence of three DNA segments, ranging from 27 to 84 nt. The complex organization of these 'different zones' may be attributable to a unique system of recombination.read more
Citations
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Improving plant breeding with exotic genetic libraries
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Illuminating the Evolutionary History of Chlamydiae
Matthias Horn,Astrid Collingro,Stephan Schmitz-Esser,Cora L. Beier,Ulrike Purkhold,Berthold Fartmann,Petra Brandt,Gerald Nyakatura,Marcus Droege,Dmitrij Frishman,Thomas Rattei,Hans-Werner Mewes,Michael Wagner +12 more
TL;DR: It is shown that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlam Lydiae, including a type III secretion system.
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Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche‐specific genes in the evolution of the Chlamydiaceae
Timothy D. Read,Garry S. A. Myers,Robert C. Brunham,William C. Nelson,Ian T. Paulsen,Ian T. Paulsen,John F. Heidelberg,Erik Holtzapple,Hoda Khouri,N. B. Federova,Heather A. Carty,Lowell Umayam,Daniel H. Haft,Jeremy Peterson,Maureen J. Beanan,Owen White,Steven L. Salzberg,Ru-ching Hsia,G. McClarty,Roger G. Rank,Patrik M. Bavoil,Claire M. Fraser,Claire M. Fraser +22 more
TL;DR: The genome of C.caviae was determined, representing the fourth species with a complete genome sequence from the Chlamydiaceae family of obligate intracellular bacterial pathogens, and enabling dissection of the roles played by niche-specific genes in these important bacterial pathogens.
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Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics
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Horizontal gene transfer among microbial genomes: New insights from complete genome analysis
TL;DR: The determination and analysis of complete genome sequences has led to the suggestion that horizontal gene transfer may be much more extensive than previously appreciated, but many of these studies rely on evidence that could be generated by forces other than gene transfer.
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