Journal ArticleDOI
Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway.
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It is concluded that constitutive activation of ADAM10 contributes to the growth of MCL and therefore inhibition ofADAM10 may be a useful strategy to enhance the response of M CL to other therapeutic agents.About:
This article is published in Blood.The article was published on 2011-06-09. It has received 32 citations till now. The article focuses on the topics: Cyclin D1 & Cell growth.read more
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Journal ArticleDOI
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10
Johannes Prox,Michael Willenbrock,Silvio Weber,Tobias Lehmann,Dirk Schmidt-Arras,Ralf Schwanbeck,Paul Saftig,Michael Schwake +7 more
TL;DR: The data show that TSPAN15 is a central modulator of ADAM10-mediated ectodomain shedding and Therapeutic manipulation of its expression levels may be an additional approach to specifically regulate the activity of the amyloid precursor protein alpha-secretase ADAM 10.
Journal ArticleDOI
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells
Alessandra Zingoni,Francesca Cecere,Elisabetta Vulpis,Cinzia Fionda,Rosa Molfetta,Alessandra Soriani,Maria Teresa Petrucci,Maria Rosaria Ricciardi,Daniel Fuerst,Maria Giulia Amendola,Joannis Mytilineos,Cristina Cerboni,Rossella Paolini,Marco Cippitelli,Angela Santoni +14 more
TL;DR: The combined use of chemotherapeutic drugs and metalloproteinase inhibitors enhances NK cell–mediated recognition of MM cells, preserving MIC molecules on the cell surface and suggesting that targeting of metalliproteinases in conjunction with chemotherapy could be exploited for NK cell-based immunotherAPEutic approaches, thus contributing to avoid the escape of malignant cells from stress-elicited immune responses.
Journal ArticleDOI
Anti-tumour effects of a specific anti-ADAM17 antibody in an ovarian cancer model in vivo.
TL;DR: D1(A12) has anti-ADAM17 activity in vivo, inhibits shedding of EGFR ligands and has potential for use in EGF ligand-dependent tumours.
Journal ArticleDOI
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin
TL;DR: This review attempts to summarize selected aspects of the current view of the multiple roles such proteases play in health and disease.
Journal ArticleDOI
Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE-/- Mice.
Ye Yao,Weidong Sun,Qingfeng Sun,Bao Jing,Si-Qi Liu,Xin-Yu Liu,Guanghui Shen,Ru Chen,Haiyang Wang +8 more
TL;DR: PLT-Exo overexpressing miR-25-3p attenuates ox-LDL-induced CVEC inflammation in ApoE−/− mouse models of atherosclerosis.
References
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Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.
Journal ArticleDOI
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TL;DR: It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
Journal ArticleDOI
The ADAMs family of metalloproteases: multidomain proteins with multiple functions
TL;DR: This review will first discuss the properties of each of the domains of the ADAMs, then describe the involvement ofADAMs in selected biological processes, and highlight recent interesting findings suggesting roles for ADams in human disease.
Journal ArticleDOI
The ADAM metalloproteinases.
TL;DR: The ADAM family are fundamental to many control processes in development and homeostasis, and unsurprisingly they are also linked to pathological states when their functions are dysregulated, including cancer, cardiovascular disease, asthma, Alzheimer’s disease.
Journal ArticleDOI
Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma
Andreas Rosenwald,George E. Wright,Karen Leroy,Xin-You Yu,Philippe Gaulard,Randy D. Gascoyne,Wing C. Chan,Tong Zhao,Corinne Haioun,Timothy C. Greiner,Dennis D. Weisenburger,James C. Lynch,Julie M. Vose,James O. Armitage,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Jan Delabie,Elias Campo,Emili Montserrat,Armando López-Guillermo,German Ott,H. Konrad Muller-Hermelink,Joseph M. Connors,Rita M. Braziel,Thomas M. Grogan,Thomas M. Grogan,Richard I. Fisher,Richard I. Fisher,Thomas P. Miller,Thomas P. Miller,Michael LeBlanc,Michael LeBlanc,Michael Chiorazzi,Hong-Bo Zhao,Liming Yang,John Powell,Wyndham H. Wilson,Elaine S. Jaffe,Richard Simon,Richard D. Klausner,Louis M. Staudt +41 more
TL;DR: Gene expression profiling strongly supported a relationship between PMBL and Hodgkin lymphoma: over one third of the genes that were more highly expressed in PMBL than in other DLBCLs were also characteristically expressed in Hodgkinymphoma cells.