The ADAMs family of metalloproteases: multidomain proteins with multiple functions
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TLDR
This review will first discuss the properties of each of the domains of the ADAMs, then describe the involvement ofADAMs in selected biological processes, and highlight recent interesting findings suggesting roles for ADams in human disease.Abstract:
The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily. Members of the family have a modular design, characterized by the presence of metalloprotease and integrin receptor-binding activities, and a cytoplasmic domain that in many family members specifies binding sites for various signal transducing proteins. The ADAMs family has been implicated in the control of membrane fusion, cytokine and growth factor shedding, and cell migration, as well as processes such as muscle development, fertilization, and cell fate determination. Pathologies such as inflammation and cancer also involve ADAMs family members. Excellent reviews covering various facets of the ADAMs literature-base have been published over the years and we recommend their examination (Black and White 1998; Schlondorff and Blobel 1999; Primakoff and Myles 2000; Evans 2001; Kheradmand and Werb 2002). In this review, we will first discuss the properties of each of the domains of the ADAMs. We will then go on to describe the involvement of ADAMs in selected biological processes. Then, we will highlight recent interesting findings suggesting roles for ADAMs in human disease. Finally, we look to the future and discuss some of the open issues in ADAMs function and regulation.read more
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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
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References
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
Journal ArticleDOI
The biology of chemokines and their receptors.
Devora L. Rossi,Albert Zlotnik +1 more
TL;DR: Some of the chemokines' biological effects in vivo and in vitro, described in the last few years are discussed, and the implications of these findings when considering chemokine receptors as therapeutic targets are discussed.
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Tissue inhibitors of metalloproteinases: evolution, structure and function.
TL;DR: The evolution of TIMPs, the recently elucidated high-resolution structures of TIMP and their complexes with metalloproteinases, and the results of mutational and other studies of structure-function relationships that have enhanced understanding of the mechanism and specificity of the inhibition of MMPs by TIMPs are highlighted.
Journal ArticleDOI
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Gallia Levy,William C. Nichols,Eric C.-Y. Lian,Tatiana Foroud,Jeanette N. McClintick,Beth McGee,Angela Y. Yang,David R. Siemieniak,Kenneth R. Stark,Ralph A. Gruppo,Ravindra Sarode,Susan B. Shurin,Visalam Chandrasekaran,Sally P. Stabler,Hernan Sabio,Eric E. Bouhassira,Jefferson D. Upshaw,David Ginsburg,Han-Mou Tsai +18 more
TL;DR: In this article, the ADAMTS family of zinc metalloproteinase genes (ADAMTS13) was identified as the molecular mechanism responsible for TTP, and it was shown that the deficiency of ADADTS13 is the molecular mechanisms responsible for the development of TTP.
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