Journal ArticleDOI
Contact-dependent cleavage of Jagged1 in oocytes reveals potential bidirectional notch signaling during follicular growth in the mouse.
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This article is published in Biology of Reproduction.The article was published on 2021-09-02. It has received 1 citations till now. The article focuses on the topics: Granulosa cell & Cleavage (embryo).read more
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Transzonal projections: Essential structures mediating intercellular communication in the mammalian ovarian follicle
TL;DR: This work discusses two mechanisms that may generate TZPs-stretching at pre-existing points of granulosa cell-oocyte contact and elaboration of new processes that push through the zona pellucida-as well as gene products implicated in their formation or function.
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Notch signalling in context
TL;DR: The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes.
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The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
TL;DR: It is concluded that Delta and Jagged undergo ADAM-mediated ectodomain processing followed by PS-mediated intramembrane proteolysis to release signaling fragments, indicating that Notch and its cognate ligands are processed by the same molecular machinery and may antagonistically regulate each other's signaling.
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Notch Signaling Regulates Ovarian Follicle Formation and Coordinates Follicular Growth
TL;DR: It is demonstrated that important functions for Jagged1 and Notch2 in the resolution of germ cell syncytia and the coordination of somatic and germ cell growth within follicles of the mouse ovary are demonstrated.
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Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles
Jingxia Xu,Thomas Gridley +1 more
TL;DR: This work demonstrates that Notch2-mediated signaling in the somatic-cell lineage of the mouse ovary regulates oocyte apoptosis non-cell autonomously, and is essential for regulating breakdown of germ-cell nests and formation of primordial follicles.
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Jagged1 (JAG1): Structure, expression, and disease associations.
TL;DR: Alagille syndrome, which primarily affects the liver, heart, skeleton, eye, face, kidney and vasculature is caused by loss of function mutations in JAG1, demonstrating that haploinsufficiency for Jag1 is disease causing, at least in these tissues.