Journal ArticleDOI
Converting-enzyme inhibitors in the treatment of hypertension.
TLDR
In 1982, Vidt and colleagues reviewed the pharmacokinetics, mechanisms of action, and therapeutic usefulness of captopril, the first of a new class of antihypertensives, converting-enzyme inhibitor, and found it to be of high therapeutic usefulness.Abstract:
IN 1982, Vidt and colleagues reviewed the pharmacokinetics, mechanisms of action, and therapeutic usefulness of captopril, the first of a new class of antihypertensives, converting-enzyme inhibitor...read more
Citations
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Journal ArticleDOI
Drugs targeting the renin–angiotensin–aldosterone system
TL;DR: Drugs that inhibit or antagonize components of the renin–angiotensin–aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.
Journal ArticleDOI
Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and Lisinopril
Jackson T. Wright,J. Kay Dunn,Jeffrey A. Cutler,Barry R. Davis,William C. Cushman,Charles E. Ford,L. Julian Haywood,Frans H. H. Leenen,Karen L. Margolis,Vasilios Papademetriou,Jeffrey L. Probstfield,Paul K. Whelton,Gabriel B. Habib +12 more
TL;DR: While the improved outcomes with chlorthalidone were more pronounced for some outcomes in blacks than in nonblacks, thiazide-type diuretics remain the drugs of choice for initial therapy of hypertension in both black and nonblack hypertensive patients.
Journal ArticleDOI
Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The Task Force on ACE-inhibitors of the European Society of Cardiology.
Jose Lopez-Sendon,Karl Swedberg,John J.V. McMurray,Juan Tamargo,Aldo P. Maggioni,Henry J. Dargie,Michal Tendera,Finn Waagstein,Jan Kjekshus,Philippe Lechat,Christian Torp-Pedersen +10 more
TL;DR: The ESC Committee for Practice Guidelines (CPG), Silvia G. Priori (Chairperson) (Italy), Maria Angeles Alonso Garcia (Spain), Jean-Jacques Blanc (France), Andrzej Budaj (Poland), Martin Cowie (UK), Veronica Dean (France, Jaap Deckers (The Netherlands), Enrique Fernandez Burgos (Spain) as mentioned in this paper, John Lekakis (Greece), Bertil Lindahl (Sweden), Gianfranco Mazzotta (Italy).
Journal ArticleDOI
Angiotensin-converting enzyme inhibitor fetopathy.
TL;DR: It is recommended that ACE inhibitors not be used in pregnancy, particularly in the second and third trimesters, because of the debilitating and lethal nature of the fetal damage when it occurs.
Journal ArticleDOI
Functional and Biochemical Analysis of Angiotensin II–Forming Pathways in the Human Heart
Arlene Wolny,Jean-Paul Clozel,Josiane Rein,Paul Mory,Paul Vogt,Marko Turino,Wolfgang Kiowski,Walter Fischli +7 more
TL;DR: The authors' studies indicate an incomplete ACE inhibition in human heart tissue after chronic ACE inhibitor therapy, and drugs such as renin inhibitors and Ang II receptor blockers might be able to induce a more complete blockade of the renin-angiotensin system, providing a more efficacious therapy.
References
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Journal ArticleDOI
Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents
TL;DR: A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled a new class of potent and specific inhibitors, carboxyalkanoyl and mercaptoalkanoysl derivatives of proline, to be designed.
Journal ArticleDOI
The Effects of Antihypertensive Therapy on the Quality of Life
S H Croog,Sol Levine,Marcia A. Testa,Brown B,Bulpitt Cj,Jenkins Cd,Klerman Gl,Gordon H. Williams +7 more
TL;DR: It is shown that antihypertensive agents have different effects on the quality of life and that these can be meaningfully assessed with available psychosocial measures.
Journal ArticleDOI
The 1988 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure
Aram V. Chobanian,Michael H. Alderman,Vincent DeQuattro,Edward D. Frohlich,Ray W. Gifford,Martha N. Hill,Norman M Kaplan,Herbert G. Langford,Michael A. Moore,William A. Nickey,Jerome G. Porush,Gerald E. Thomson,Mary Winston,Harriet P. Dustan,Iqbal Krishan,Marvin Moser,Jeffrey A. Cutler,Michael J. Horan,Gerald H. Payne,Edward J. Roccella,Stephen M. Weiss +20 more
TL;DR: This report updates findings of previous reports in several respects: it broadens the step-care approach to provide more flexibility for clinicians; encourages greater patient involvement in the treatment program; emphasizes a consideration of the quality of life in the management of patients; and addresses the cost of care.
Journal ArticleDOI
The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies.
TL;DR: A number of clinical studies have been performed in an attempt to dissect the particular component or components of the diabetic state responsible for these early elevations in glomerular filtration rate, and no single factor appears to account fully for this phenomenon.
Journal ArticleDOI
Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney.
Donald E. Hricik,Philip J. Browning,Richard Kopelman,Warren E. Goorno,Nicolaos E. Madias,Victor J. Dzau +5 more
TL;DR: A variety of mechanisms have been postulated to account for captopril-based renal failure and these include angiotensin-converting-enzyme inhibitor-like mechanisms, cell reprograming, and “spatially masked” mechanisms.
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Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. results of the survival and ventricular enlargement trial
Marc A. Pfeffer,Eugene Braunwald,Lemuel A. Moyé,Lofty L. Basta,Edward J. Brown,Thomas E. Cuddy,Barry R. Davis,Edward M. Geltman,Steven Goldman,Greg C. Flaker,Marc Klein,Gervasio A. Lamas,Milton Packer,Jacques R. Rouleau,Jean L. Rouleau,John D. Rutherford,John H. Wertheimer,C. Morton Hawkins +17 more