Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Giulia Ferrannini,Giulia Ferrannini,Maria Laura Manca,Marco Magnoni,Felicita Andreotti,Daniele Andreini,Roberto Latini,Attilio Maseri,Aldo P. Maggioni,Rachel Ostroff,Stephen A. Williams,Ele Ferrannini +11 more
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TLDR
It is concluded that CAD severity and quality do not differ between participants with T2D and without diabetes, and renin, GDF15, and adiponectin are shared markers by T2d and CAD; several proteins are specifically associated with T1D or CAD; and in T3D, lower renin levels may protect against CAD.Abstract:
OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation—a cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD− (clean coronaries) and CAD+ (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD. RESULTS Though CAD+ was more prevalent among participants with T2D (HbA1c 6.7 ± 1.1%) than those without diabetes (56 vs. 30%, P CONCLUSIONS We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.read more
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Epigenetic Modifications and Non-Coding RNA in Diabetes-Mellitus-Induced Coronary Artery Disease: Pathophysiological Link and New Therapeutic Frontiers
F. R. Prandi,Dalgisio Lecis,Federica Illuminato,Maria Teresa Milite,Roberto Celotto,Stamatios Lerakis,Francesco Romeo,Francesco Barillà +7 more
TL;DR: This review addresses the current knowledge on the pathophysiological links between DM and CAD with a focus on the role of epigenetic modifications, including DNA methylation, histone modifications and noncoding RNA control.
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The Imaging Council of the American College of Cardiology.
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Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
N. Skenteris,Till Seime,Anna Witasp,Eva Karlöf,Grzegorz B. Wasilewski,Marina Heuschkel,Armand M. G. Jaminon,Loureen B. Oduor,Robert Dzhanaev,Malin Kronqvist,Mariette Lengquist,Frederique E C M Peeters,Magnus Söderberg,Rebecka Hultgren,Joy Roy,Lars Maegdefessel,Hildur Arnardottir,Eva Bengtsson,Isabel Gonçalves,Thomas Quertermous,Claudia Goettsch,Peter Stenvinkel,Leon J. Schurgers,Ljubica Perisic Matic +23 more
TL;DR: A consistent association of both circulating and tissue OMD levels with cardiovascular calcification is reported, highlighting the potential of OMD as a clinical biomarker.
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Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes.
TL;DR: Recent advances in high-throughput technologies that provide comprehensive, scalable profiling of the plasma proteome with the potential to improve prediction and mechanistic understanding of type 2 diabetes (T2D) are reviewed.
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Aptamer-based applications for cardiovascular disease
TL;DR: A combination of von Willebrand Factor and nucleic acid aptamers can effectively inhibit the progression of blood clots, presenting a positive diagnosis and therapeutic effect, as well as laying a novel theory and strategy to improve biocompatibility paclitaxel drug balloon or implanted stent in the future.
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