Journal ArticleDOI
Coumarins: old compounds with novel promising therapeutic perspectives.
Maria E. Riveiro,N. de Kimpe,Albertina G. Moglioni,Ramiro Vázquez,Federico Monczor,Carina Shayo,Carlos Davio +6 more
TLDR
The present review highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents and the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.Abstract:
Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory and anti-oxidant effects, as well as anti-microbial and enzyme inhibition properties. The recognition of key structural features within coumarin family is crucial for the design and development of new analogues with improved activity and for the characterization of their mechanism of action and potential side effects. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity for other pharmacological targets and define their mechanism of action to achieve new therapeutic drugs. The present review highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.read more
Citations
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Journal ArticleDOI
Bright Building Blocks for Chemical Biology
Luke D. Lavis,Ronald T. Raines +1 more
TL;DR: Traditional and modern synthetic routes to small-molecule fluorophores are surveyed and recent biological insights attained with customized fluorescent probes are highlighted to inspire the design and creation of new high-precision tools that empower chemical biologists.
Journal ArticleDOI
Current Developments of Coumarin Compounds in Medicinal Chemistry
TL;DR: The whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains are presented.
Journal ArticleDOI
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
Journal ArticleDOI
Coumarins as antioxidants.
Irena Kostova,Sumati Bhatia,P. Grigorov,Stefan Balkansky,V. S. Parmar,Ashok K. Prasad,Luciano Saso +6 more
TL;DR: This review considers and incorporates the most recently published literature on coumarins as related to their antioxidant properties, and updates and expands the 2006 review by the same author.
Journal ArticleDOI
Anticancer activity of new coumarin substituted hydrazide-hydrazone derivatives.
TL;DR: It is concluded that 6-brominated coumarin hydrazide-hydrazone derivatives 7c could be a potent anticancer drug to overcome drug resistance in cancer and it could be highly beneficial for patients in the clinic.
References
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Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
TL;DR: The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.
Journal ArticleDOI
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
TL;DR: Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Book
Coumarins : biology, applications, and mode of action
R. O'Kennedy,R. D. Thornes +1 more
TL;DR: This book presents the background, Rationale and current development of Coumarin (1,2--benzopyrone) as a Potential Therapeutic Agents as well as suggested Modes of Action and Some Comments on their Significance.
Journal ArticleDOI
Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability.
TL;DR: In this paper, the ability of various plant flavonoids to inhibit 5-lipoxygenase and cyclooxygenases activities in rat peritoneal leukocytes, and to stimulate DNA degradation caused by the antibiotic bleomycin in the presence of ferric ions were investigated.
Journal ArticleDOI
The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds
TL;DR: Coumarin-Related Compounds and Drug Metabolism Reviews: Vol.
Related Papers (5)
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
Aoife Lacy,Richard O'Kennedy +1 more