Coupling governs entrainment range of circadian clocks.
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Differences between master and the peripheral clocks suggest that coupling‐induced rigidity in the SCN filters environmental noise to create a robust circadian system.Abstract:
Circadian clocks are endogenous oscillators driving daily rhythms in physiology and behavior. Synchronization of these timers to environmental light–dark cycles (‘entrainment’) is crucial for an organism’s fitness. Little is known about which oscillator qualities determine entrainment, i.e., entrainment range, phase and amplitude. In a systematic theoretical and experimental study, we uncovered these qualities for circadian oscillators in the suprachiasmatic nucleus (SCN—the master clock in mammals) and the lung (a peripheral clock): (i) the ratio between stimulus (zeitgeber) strength and oscillator amplitude and (ii) the rigidity of the oscillatory system (relaxation rate upon perturbation) determine entrainment properties. Coupling among oscillators affects both qualities resulting in increased amplitude and rigidity. These principles explain our experimental findings that lung clocks entrain to extreme zeitgeber cycles, whereas SCN clocks do not. We confirmed our theoretical predictions by showing that pharmacological inhibition of coupling in the SCN leads to larger ranges of entrainment. These differences between master and the peripheral clocks suggest that coupling-induced rigidity in the SCN filters environmental noise to create a robust circadian system.read more
Citations
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References
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Book
Nonlinear Oscillations, Dynamical Systems, and Bifurcations of Vector Fields
TL;DR: In this article, the authors introduce differential equations and dynamical systems, including hyperbolic sets, Sympolic Dynamics, and Strange Attractors, and global bifurcations.
A Reflection on Nonlinear Oscillations, Dynamical Systems, and Bifurcations of Vector Fields
J. Guckenheimer,P. J. Holmes +1 more
TL;DR: In this paper, the authors introduce differential equations and dynamical systems, including hyperbolic sets, Sympolic Dynamics, and Strange Attractors, and global bifurcations.
Book
Synchronization: A Universal Concept in Nonlinear Sciences
TL;DR: This work discusseschronization of complex dynamics by external forces, which involves synchronization of self-sustained oscillators and their phase, and its applications in oscillatory media and complex systems.