Journal ArticleDOI
Creatine kinase in regulation of heart function and metabolism. I. Further evidence for compartmentation of adenine nucleotides in cardiac myofibrillar and sarcolemmal coupled ATPase-creatine kinase systems.
TLDR
The rate of immediate myofibrillar MgADP rephosphorylation in the endogenous creatine-kinase reaction was observed to be governed by the concentration of phosphocreatine in accordance with the kinetics of this enzyme.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1984-04-16. It has received 83 citations till now. The article focuses on the topics: Creatine kinase & Phosphocreatine.read more
Citations
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Journal ArticleDOI
The ADP and ATP transport in mitochondria and its carrier
TL;DR: Different from some more specialised short reviews, here a general although not encyclopaedic survey of the function, metabolic role, structure and mechanism of the ADP/ATP transport in mitochondria is presented.
Journal ArticleDOI
The creatine kinase system and pleiotropic effects of creatine
TL;DR: The stimulating effects of Cr for muscle and bone growth and maintenance, and especially in neuroprotection, are now recognized and the first clinical studies are underway.
Journal ArticleDOI
Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism
Journal ArticleDOI
Creatine kinase in non-muscle tissues and cells
Theo Wallimann,Wolfram Hemmer +1 more
TL;DR: New findings concerning the isoenzyme-specific cellular localization and subcellular compartmentation of CK isoenzymes in photoreceptor cells, in glial and neuronal cells of the cerebellum and in spermatozoa are reported on.
Journal ArticleDOI
Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
Mengke Qu,Qing Lin,Luyi Huang,Yao Fu,Luyao Wang,Shanshan He,Yu Fu,Shengyong Yang,Zhirong Zhang,Ling Zhang,Xun Sun +10 more
TL;DR: It is suggested that blood exosomes can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.
References
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Journal ArticleDOI
Regulation and Kinetics of the Actin-Myosin-ATP Interaction
R S Adelstein,E Eisenberg +1 more
Journal ArticleDOI
Transport of energy in muscle: the phosphorylcreatine shuttle
Samuel P. Bessman,Paul J. Geiger +1 more
TL;DR: It was proposed in 1951 that contracting muscle fibers liberate creatine, which acts to produce an acceptor effect--later called respiratory control--on the muscle mitochondria, which established a molecular basis for a phosphorylcreatine-creatine shuttle for energy transport in heart and skeletal muscle.
Journal ArticleDOI
Creatine kinase of rat heart mitochondria. Coupling of creatine phosphorylation to electron transport.
TL;DR: These and other properties suggest that in addition to the ∼P storage function usually postulated for it, the phosphocreatine-creatine kinase system serves to smooth out or buffer the rate of respiration of heart mitochondria at a high and constant rate and to channel ∼P to the contractile system via the mitochondrial and sarcoplasmic isoenzymes of creatine kinase.
Journal ArticleDOI
Effects of ischemia on function and metabolism of the isolated working rat heart.
TL;DR: Two techniques have been developed for inducing whole-heart ischemia in the isulated working rat heart that allowed total coronary Aow to be reduced in hearts that were performing external mechanical work.
Journal ArticleDOI
Functional compartmentation of ATP and creatine phosphate in heart muscle
Sigmundur Gudbjarnason,Sigmundur Gudbjarnason,Peter Mathes,Peter Mathes,K.G. Ravens,K.G. Ravens +5 more
TL;DR: The early cessation of contractile activity in ischemic myocardial cells appears to be the result of a reduction in the rate of regeneration of a small pool of extra-mitochondrial ATP available for muscle contraction and other ATP requiring processes such as ion transport.
Related Papers (5)
Transport of energy in muscle: the phosphorylcreatine shuttle
Samuel P. Bessman,Paul J. Geiger +1 more