Journal ArticleDOI
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
TLDR
Control of hyperglycaemia might reduce the severity of these complications of critical illness, and early rehabilitation in the intensive care unit might improve the functional recovery and independence of patients.Abstract:
Critical illness polyneuropathy (CIP) and myopathy (CIM) are complications of critical illness that present with muscle weakness and failure to wean from the ventilator. In addition to prolonging mechanical ventilation and hospitalisation, CIP and CIM increase hospital mortality in patients who are critically ill and cause chronic disability in survivors of critical illness. Structural changes associated with CIP and CIM include axonal nerve degeneration, muscle myosin loss, and muscle necrosis. Functional changes can cause electrical inexcitability of nerves and muscles with reversible muscle weakness. Microvascular changes and cytopathic hypoxia might disrupt energy supply and use. An acquired sodium channelopathy causing reduced muscle membrane and nerve excitability is a possible unifying mechanism underlying CIP and CIM. The diagnosis of CIP, CIM, or combined CIP and CIM relies on clinical, electrophysiological, and muscle biopsy investigations. Control of hyperglycaemia might reduce the severity of these complications of critical illness, and early rehabilitation in the intensive care unit might improve the functional recovery and independence of patients.read more
Citations
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Journal ArticleDOI
Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study
James C. Jackson,Pratik P. Pandharipande,Pratik P. Pandharipande,Timothy D. Girard,Timothy D. Girard,Nathan E. Brummel,Jennifer L. Thompson,Christopher G. Hughes,Christopher G. Hughes,Brenda T. Pun,Eduard E. Vasilevskis,Alessandro Morandi,Ayumi Shintani,Ramona O. Hopkins,Ramona O. Hopkins,Gordon R. Bernard,Robert S. Dittus,Robert S. Dittus,E. Wesley Ely,E. Wesley Ely +19 more
TL;DR: In this paper, the authors used linear and proportional odds logistic regression to assess the independent associations between age and duration of delirium with mental health and functional disabilities in patients undergoing treatment in medical or surgical ICUs.
Journal ArticleDOI
Clinical review: intensive care unit acquired weakness
TL;DR: Prognosis appears compromised when the cause of ICUAW involves critical illness polyneuropathy, whereas isolated critical illness myopathy may have a better prognosis.
Journal ArticleDOI
Neurological Complications during Treatment of Middle East Respiratory Syndrome.
Jee Eun Kim,Jae Hyeok Heo,Hye Ok Kim,Sook Hee Song,Sang Soon Park,Tai Hwan Park,Jin Young Ahn,Min Ky Kim,Jae-Phil Choi +8 more
TL;DR: Neuromuscular complications are not rare during MERS treatment, and they may have previously been underdiagnosed, according to a cohort of 23 patients treated at a single designated hospital during the 2015 outbreak in the Republic of Korea.
Journal ArticleDOI
Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis.
Greet Hermans,Helena Van Mechelen,Beatrix Clerckx,Tine Vanhullebusch,Dieter Mesotten,Alexander Wilmer,Michael P Casaer,Philippe Meersseman,Yves Debaveye,Sophie Van Cromphaut,Pieter Wouters,Rik Gosselink,Greet Van den Berghe +12 more
TL;DR: It is suggested that ICU-acquired weakness worsens acute morbidity and increases healthcare-related costs and 1-year mortality and the 1- year risk of death was further increased if weakness persisted and was more severe as compared with recovery of weakness at ICU discharge.
Journal ArticleDOI
Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial
Greet Hermans,Michael P Casaer,Beatrix Clerckx,Fabian Güiza,Tine Vanhullebusch,Sarah Derde,Philippe Meersseman,Inge Derese,Dieter Mesotten,Pieter Wouters,Sophie Van Cromphaut,Yves Debaveye,Rik Gosselink,Jan Gunst,Alexander Wilmer,Greet Van den Berghe,Ilse Vanhorebeek +16 more
TL;DR: Tolerating a substantial macronutrient deficit early during critical illness did not affect muscle wasting, but allowed more efficient activation of autophagic quality control of myofibres and reduced weakness.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Margaret S. Herridge,Angela M. Cheung,Catherine M. Tansey,Andrea Matte-Martyn,Natalia Diaz-Granados,Fatma Al-Saidi,Andrew B. Cooper,Cameron B. Guest,C. David Mazer,Sangeeta Mehta,Thomas E. Stewart,Aiala Barr,Deborah J. Cook,Arthur S. Slutsky +13 more
TL;DR: In this article, the authors evaluated 109 survivors of the acute respiratory distress syndrome 3, 6, and 12 months after discharge from the intensive care unit, and found that muscle weakness and fatigue were the reasons for their functional limitation.
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