Journal ArticleDOI
Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
TLDR
It is reported that crocin is a unique and potent antioxidant that combats oxidative stress in neurons and was more effective than those of alpha-tocopherol at the same concentration.About:
This article is published in Neuroscience Letters.The article was published on 2004-05-13. It has received 246 citations till now. The article focuses on the topics: Crocin & Lipid peroxidation.read more
Citations
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Plant in vitro culture for the production of antioxidants : A review
TL;DR: In the present review some of the most active antioxidants derived from plant tissue cultures are described; they have been divided into the main chemical groups of polyphenols and isoprenoids, and several examples also from other chemical classes are presented.
Journal ArticleDOI
Bioactivity assessment and toxicity of crocin: A comprehensive review
TL;DR: A comprehensive and updated report of empirical investigations on bioactivities and biological characteristics of crocin is provided in this paper, where it is also worth noting that the crocin principle of saffron exhibited high efficacy along with no major toxicity in experimental models.
Journal ArticleDOI
Inhibitory Activity on Amyloid-β Aggregation and Antioxidant Properties of Crocus sativus Stigmas Extract and Its Crocin Constituents
Magdalini A. Papandreou,Charalambos D. Kanakis,Moschos G. Polissiou,Spyros Efthimiopoulos,Paul Cordopatis,Marigoula Margarity,Fotini N. Lamari +6 more
TL;DR: The main carotenoid constituent, trans-crocin-4, the digentibiosyl ester of crocetin, inhibited Abeta fibril formation and deposition at lower concentrations than dimethylcrocet in a concentration and time-dependent manner, suggesting the possible use of C. sativus stigma constituents for inhibition of aggregation and deposition of Abeta in the human brain.
Journal ArticleDOI
Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin
TL;DR: The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.
References
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Caspases: Enemies Within
TL;DR: This work has shown that understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
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Death receptors: signaling and modulation
Avi Ashkenazi,Vishva M. Dixit +1 more
TL;DR: Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival.
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Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
TL;DR: If NGF was added back to the culture medium after the period of peak ROS generation, apoptosis was completely prevented, suggesting that ROS production serves as an early signal, rather than a toxic agent, to mediate apoptosis.
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Bcl-2 family: Life-or-death switch
TL;DR: An overview of recent findings on the role of Bcl‐2 family members in the life‐or‐death decision of a cell is provided.
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Oxygen free radical involvement in ischemia and reperfusion injury to brain
TL;DR: Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.
Related Papers (5)
Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
Kazuho Abe,Hiroshi Saito +1 more