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Journal ArticleDOI

Cryopreservation of human embryos and its contribution to in vitro fertilization success rates

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TLDR
Interestingly, success rates after frozen-thawed embryo transfer are now nearing the success rates of fresh embryo transfer, which supports the hypothesis of so called freeze-all strategies in IVF, in which all embryos are frozen and no fresh transfer is conducted, to optimize success rates.
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This article is published in Fertility and Sterility.The article was published on 2014-07-01. It has received 223 citations till now. The article focuses on the topics: Embryo transfer & Embryo cryopreservation.

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Citations
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Journal ArticleDOI

Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes.

TL;DR: EFET significantly decreases the risk of moderate and severe OHSS, albeit at the expense of an increased risk of pre-eclampsia, and the effectiveness of eFET in comparison to fresh embryo transfer in different subgroups of patients undergoing IVF/ICSI cycles is evaluated.
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Cryopreservation and its clinical applications.

TL;DR: Continuous understanding of the physical and chemical properties that occur in the freezing and thawing cycle will be necessary for the successful cryopreservation of cells or tissues and their clinical applications.
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Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization

TL;DR: The results show that MPA is an effective oral alternative for the prevention of premature LH surge in woman undergoing COH and will help establish a new regimen for ovarian stimulation in combination with embryo cryopreservation.
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Fresh versus frozen embryo transfers in assisted reproduction

TL;DR: There was no clear evidence of a difference in cumulative live birth rate between the freeze-all strategy and the conventional IVF/ICSI strategy, but the evidence was of moderate to low quality due to serious risk of bias and (for some outcomes) serious imprecision.
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Time of Implantation of the Conceptus and Loss of Pregnancy

TL;DR: In this article, the authors collected daily urine samples for up to six months from 221 women attempting to conceive after ceasing to use contraception and found that the first appearance of chorionic gonadotropin occurred 6 to 12 days after ovulation.
References
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Journal ArticleDOI

Ice-free cryopreservation of mouse embryos at -196 degrees C by vitrification.

TL;DR: In this article, the authors used mouse embryos to examine the feasibility of obtaining high survival following vitrification of both the intra and extracellular solutions and report that in properly controlled conditions embryos seem to survive in high proportions after cryopreservation in the absence of ice.
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Implantation and the survival of early pregnancy.

TL;DR: This review summarizes current information about these steps, including some of the molecular mechanisms that mediate them and how they may go awry, with consequent loss of the pregnancy.
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Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies

TL;DR: Singleton pregnancies from assisted reproduction have a significantly worse perinatal outcome than non-assisted singleton pregnancies, but this is less so for twin pregnancies.
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Open Pulled Straw (OPS) vitrification: a new way to reduce cryoinjuries of bovine ova and embryos.

TL;DR: The vitrification by the Open Pulled Straw method of in vitro produced bovine embryos at various stages of development offers a new way to solve basic problems of reproductive cryobiology and may have practical impact on animal biotechnology and human assisted reproduction.
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Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing.

TL;DR: The present study derives a quantitative relation between the amount of water in a cell and temperature using a differential equation involving cooling rate, surface-volume ratio, membrane permeability to water, and the temperature coefficient of the permeability constant.
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