CTCF, YB-1, c-myc, and p53 expressions of primary human hypertrophic scar and normal fibroblast skin cells in response to novel chitosan derivatives sheet
Mohammad Syaiful Bahari Abdull Rasad,Mohammad Syaiful Bahari Abdull Rasad,Mohammad Syaiful Bahari Abdull Rasad,Ahmad Sukari Halim,Kamaruddin Hashim,Ahmad Hazri Abdul Rashid,Lim Chin Keong,Shaharum Shamsuddin +7 more
TLDR
The novel chitosan derivatives sheet in this study may play roles in the control of cell growth and proliferation of human hypertrophic scar and normal fibroblast skin cells.About:
This article is published in Chinese Journal of Biotechnology.The article was published on 2008-12-01 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Hypertrophic scar & Fibroblast.read more
Citations
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In vitro evaluation of novel chitosan derivatives sheet and paste cytocompatibility on human dermal fibroblasts
Mohammad Syaiful Bahari Abdull Rasad,Mohammad Syaiful Bahari Abdull Rasad,Mohammad Syaiful Bahari Abdull Rasad,Ahmad Sukari Halim,Kamaruddin Hashim,Ahmad Hazri Abdul Rashid,Norimah Yusof,Shaharum Shamsuddin +7 more
TL;DR: The results indicate that both chitosan derivative sheets and pastes have appropriate cytocompatibility and appear promising as safe biomaterials with potential wound healing applications.
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Chitosan-collagen based film for controlled delivery of a combination of short life anesthetics.
Antonio Di Martino,Antonio Di Martino,Alexander Drannikov,Natalia S. Surgutskaia,Kadir Ozaltin,Pavel S. Postnikov,Trusova E. Marina,Vladimir Sedlarik +7 more
TL;DR: In vitro cytotoxicity and cell proliferation tests performed on human dermal fibroblast demonstrate the biocompatibility and lack of cytot toxicity of the prepared formulations.
References
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Induction of apoptosis in fibroblasts by c-myc protein
Gerard I. Evan,Andrew H. Wyllie,Christopher S. Gilbert,Trevor Littlewood,Hartmut Land,Mary W. Brooks,Catherine M. Waters,Linda Z. Penn,David C. Hancock +8 more
TL;DR: It is demonstrated that deregulated c-myc expression induces apoptosis in cells growth arrested by a variety of means and at various points in the cell cycle.
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Chitin/chitosan: modifications and their unlimited application potential—an overview
TL;DR: The net cationicity as well as the presence of multiple reactive functional groups in the molecule make chitosan a sought-after biomolecule and offers scope for manipulation for preparing a broad spectrum of derivatives for specific end use applications in diversified areas.
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Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
TL;DR: The premature induction of apoptosis in cells harboring a deregulated c-myc gene suggests that apoptosis may be an important mechanism in the elimination of hematopoietic cells Harboring mutations, such as constitutive c- myc expression, which imbalance normal cell cycle regulatory controls.
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An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.
Galina N. Filippova,Sara R. Fagerlie,Elena Klenova,C Myers,Y Dehner,G Goodwin,Paul E. Neiman,Steven J. Collins,Victor V. Lobanenkov +8 more
TL;DR: It is shown that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences, and provides the first feasible explanation of how certain homologous genes of different vertebrate species are regulated by the same factor and maintain similar expression patterns despite significant promoter sequence divergence.
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Potential applications of chitosan in veterinary medicine
Sevda Şenel,S.J. McClure +1 more
TL;DR: The veterinary drug delivery areas most likely to benefit from chitosan are the delivery of chemotherapeutics such as antibiotics, antiparasitics, anaesthetics, painkillers and growth promotants to mucosal epithelium for absorption for local or systemic activity, and the Delivery of immunomodulatory agents to the mucosal associated lymphoid tissue for induction or modulation of local immune responses.