Journal ArticleDOI
Curcumin: The story so far
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TLDR
Sufficient data currently exist to advocate phase II clinical evaluation of oral curcumin in patients with invasive malignancy or pre-invasive lesions of the gastrointestinal tract, particularly the colon and rectum.About:
This article is published in European Journal of Cancer.The article was published on 2005-09-01. It has received 1574 citations till now. The article focuses on the topics: Curcumin.read more
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Book ChapterDOI
Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Journal ArticleDOI
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Navneet Dhillon,Bharat B. Aggarwal,Robert A. Newman,Robert A. Wolff,Ajaikumar B. Kunnumakkara,James L. Abbruzzese,Chaan S. Ng,Vladimir Badmaev,Razelle Kurzrock +8 more
TL;DR: Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer.
Book ChapterDOI
Antioxidant and anti-inflammatory properties of curcumin.
TL;DR: Both antioxidant and anti-inflammatory properties of curcumin are described, the mode of action ofCurcumin, and its therapeutic usage against different pathological conditions are described.
Journal ArticleDOI
Dietary Polyphenols and Their Biological Significance
TL;DR: The biological mechanisms of action and protective effects of dietary polyphenols are described, and the most recent literature on the subject is covered.
Journal ArticleDOI
Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention
TL;DR: This review covers the most recent literature to summarize structural categories and molecular anticancer mechanisms of phenolic compounds from medicinal herbs and dietary plants.
References
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Journal ArticleDOI
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
John D. Hayes,David J. Pulford +1 more
TL;DR: The biochemical functions of GST are described to show how individual isoenzymes contribute to resistance to carcinogens, antitumor drugs, environmental pollutants, and products of oxidative stress, and to allow identification of factors that may modulate resistance to specific noxious chemicals.
Journal Article
Anticancer potential of curcumin: preclinical and clinical studies.
TL;DR: Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Journal ArticleDOI
Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
TL;DR: To explore the role of cyclooxygenase (COX) in endothelial cell migration and angiogenesis, two in vitro model systems involving coculture of endothelial cells with colon carcinoma cells are used.
Journal ArticleDOI
Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.
TL;DR: The realization that tumor growth requires new blood vessels and the identification of chemical factors that mediate angiogenesis have broadened the understanding of pathologic processes and opened new avenues to the diagnosis and treatment of these diseases.
Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Ann-Lii Cheng,Hsu Ch,Lin Jk,Hsu Mm,Yunn-Fang Ho,Shen Ts,Ko Jy,Lin Jt,Bor-Ru Lin,Ming-Shiang W,Yu Hs,Shiou-Hwa Jee,Chen Gs,Chen Tm,Chi-An Chen,Lai Mk,Yeong-Shiau Pu,Min-Hsiung Pan,Wang Yj,Tsai Cc,Hsieh Cy +20 more
TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.