Journal ArticleDOI
Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions.
TLDR
In this review, recent progress in CD‐based supramolecular nano assemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented.Abstract:
Cyclodextrins (CDs), which are a class of cyclic oligosaccharides extracted from the enzymatic degradation of starch, are often utilized in molecular recognition and assembly constructs, primarily via host-guest interactions in water. In this review, recent progress in CD-based supramolecular nanoassemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented, including pH- and redox-responsive drug and gene delivery, enzyme-activated specific cargo release, photoswitchable morphological interconversion, microtubular aggregation, and cell-cell communication, as well as a geomagnetism-controlled nanosystem for the suppression of tumor invasion and metastasis. Moreover, future perspectives and challenges in the fabrication of intelligent CD-based biofunctional materials are also discussed at the end of this review, which is expected to promote the translational development of these nanomaterials in the biomedical field.read more
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Journal ArticleDOI
Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host-Guest Interactions
Danyu Xia,Pi Wang,Xiaofan Ji,Niveen M. Khashab,Jonathan L. Sessler,Jonathan L. Sessler,Feihe Huang,Feihe Huang +7 more
TL;DR: This Review summarizes advances made in the area of functional SPNs, with a focus on original literature reports appearing in the past five years, and is organized according to the key macrocycle-based host-guest interactions used to produce various SPNs.
Journal ArticleDOI
Supramolecular cancer nanotheranostics
TL;DR: In this paper, the authors summarized the progress of supramolecular cancer nanotheranostics and provided guidance for designing new targeted theranostic agents based on extensive state-of-the-art research.
Journal ArticleDOI
Color-tunable single-fluorophore supramolecular system with assembly-encoded emission
TL;DR: An emissive system is demonstrated by combining pyrene fluorophore and acylhydrazone units, which can generate multi-color switchable fluorescent emissions at different assembled states, exhibiting a promising potential for intelligent fluorescent materials.
Journal ArticleDOI
Stimuli-Responsive AIEgens
TL;DR: In this article, the recent achievements of stimuli-responsive AIEgens in terms of seven most representative types of stimuli including force, light, polarity, temperature, electricity, ion, and pH are summarized.
References
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Stimuli-responsive nanocarriers for drug delivery
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
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Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications
Shaoyi Jiang,Zhiqiang Cao +1 more
TL;DR: Mixed-charge materials have been shown to be equivalent to zwitterionic materials in resisting nonspecific protein adsorption when they are uniformly mixed at the molecular scale.
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Metal-Organic Framework (MOF)-Based Drug/Cargo Delivery and Cancer Therapy.
Ming-Xue Wu,Ying-Wei Yang +1 more
TL;DR: A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.
Journal ArticleDOI
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Mahdi Karimi,Amir Ghasemi,Parham Sahandi Zangabad,Reza Rahighi,S. Masoud Moosavi Basri,S. Masoud Moosavi Basri,Hamed Mirshekari,Mandana Amiri,Z. Shafaei Pishabad,A. Aslani,Mahnaz Bozorgomid,Deepanjan Ghosh,Ali Beyzavi,A. Vaseghi,Amir Reza Aref,L. Haghani,Sajad Bahrami,Michael R. Hamblin,Michael R. Hamblin +18 more
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
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