CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease.
Tung Ming Leung,Natalia Nieto +1 more
TLDR
The role of CYP2E1 in ALD and NAFLD is summarized in this review, which shows that cytochrome P450 2E1 plays a critical role in ROS generation and CYP1E1 is also induced by alcohol itself.About:
This article is published in Journal of Hepatology.The article was published on 2013-02-01 and is currently open access. It has received 374 citations till now. The article focuses on the topics: Steatohepatitis & Fatty liver.read more
Citations
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Gut-liver axis in alcoholic liver disease.
TL;DR: This short review summarizes recent findings and highlights emerging trends in the gut-liver axis relevant to ALD, finding that bacterial decontamination improves ALD both in human and animal models.
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Triggering and resolution of inflammation in NASH.
TL;DR: The authors comprehensively discuss the key factors that trigger hepatic inflammation, as well as the pathways involved in inflammation resolution, which help to design targeted therapies able to halt or reverse disease progression in NASH.
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Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective.
TL;DR: This review summarizes the relationships between oxidative stress and different liver pathogenesis induced by drugs and xenobiotics, focusing upon different chronic liver injury induced by alcohol, antitubercular drugs and hyperactivity of antiretroviral drugs in HIV patients, viral hepatitis infection induced oxidative stress.
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Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation
TL;DR: This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.
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Involvement of free radicals and oxidative stress in NAFLD/NASH
TL;DR: The detailed analysis of lipid oxidation products shows the involvement of free radicals in the pathogenesis of NAFLD and NASH, taking characteristic features of free radical-mediated oxidation into consideration.
References
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Cytochrome P-4502E1: its physiological and pathological role
TL;DR: 2E1 has a unique capacity to activate many xenobiotics to hepatotoxic or carcinogenic products, mainly as a monooxygenase and secondarily via hydroxyl radicals, with transcriptional and posttranscriptional regulation.
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CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
Isabelle Leclercq,Geoffrey C. Farrell,Jaqueline Field,David R. Bell,Frank J. Gonzalez,Graham R. Robertson +5 more
TL;DR: Results show that experimental NASH is strongly associated with hepatic microsomal lipid peroxidation, and CYP4A enzymes are identified as alternative initiators of oxidative stress in the liver.
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Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.
TL;DR: There is accumulating evidence that mitochondrial dysfunction (more particularly respiratory chain deficiency) plays a key role in the physiopathology of NASH whatever its initial cause and that several drugs can prevent or even reverse NASH.
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CYP2E1 and oxidative liver injury by alcohol.
Yongke Lu,Arthur I. Cederbaum +1 more
TL;DR: This review article summarizes some of the biochemical and toxicological properties of CYP2E1 and briefly describes the use of cell lines developed to constitutively express CYP1-dependent and cytochrome P450 2E1 knockout mice in assessing the actions of CYE1.
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Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress.
TL;DR: In this paper, the authors present evidence that, in the context of hepatic steatosis, CYPs 2E1 and 4A could generate the second hit of cellular injury, particularly when antioxidant reserves are depleted.