Journal ArticleDOI
Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms.
F. Mirabelli,Salis A,Mario Vairetti,Giorgio Bellomo,Hjördis Thor,Hjördis Thor,Sten Orrenius,Sten Orrenius +7 more
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TLDR
These findings demonstrate that the multiple effects of oxidative stress on the platelet cytoskeleton are mediated by oxidative as well as by Ca2+-dependent mechanisms.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1989-05-01. It has received 143 citations till now. The article focuses on the topics: Cytoskeleton & Oxidative stress.read more
Citations
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Role of Ca2+ in toxic cell killing
TL;DR: Several biochemical mechanisms that are stimulated by a sustained increase in cytosolic Ca2+ concentration and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components are described.
Journal ArticleDOI
Glutathione: Toxicological Implications
TL;DR: The role of mitochondrial glutathione in cellular response to toxic exposures that include loss of the homeostases of Ca2+ and protein thiols is described.
Journal ArticleDOI
Oxidative stress: Free radical production in neural degeneration
TL;DR: The oxidative stress theory of neurodegeneration, on excitotoxin-induced cell damage and on impairment of mitochondrial function are focused on as three major noxae being the most likely causes of cell death either independently or in connection with each other.
Journal ArticleDOI
Cell Death Mechanisms and the Immune System
TL;DR: The immune system provides good models for cell death, a phenomenon now recognized to be of fundamental importance in many fields of biology and the nature of molecules causally involved in the dying cell can now be approached in some systems.
Journal ArticleDOI
The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself.
TL;DR: The actin cytoskeleton response to oxidants is discussed on the basis of the growing body of evidence indicating the actin system as the most sensitive constituent of the cytos skeleton to the oxidant attack.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides.
TL;DR: A rapid and sensitive high-performance liquid chromatography method for determination of nanomole levels of glutathione, glutathiona disulfide, cysteine glutathion-mixed disulfides and 20 related sulfur-containing amino acids or their derivatives has been described.
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The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
TL;DR: In the presence of cytotoxic concentrations of menadione rapid changes in intracellular thiol and Ca2+ homeostasis were observed and were associated with alterations in the surface structure of the hepatocytes which may be an early indication of cytOToxicity.