Journal ArticleDOI
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.
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The case of curcumin was studied in this article, where it was shown that it has cytotoxicity and cytoprotective activities of natural compounds, and the case of Curcumin showed that it is a compound with good properties.Abstract:
(1996). Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin. Xenobiotica: Vol. 26, No. 7, pp. 667-680.read more
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Book ChapterDOI
Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Journal Article
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Christian Jobin,Cynthia A. Bradham,Maria Pia Russo,B Juma,Acharan Narula,David A. Brenner,Ryan Balfour Sartor +6 more
TL;DR: It is concluded that curcumin potently inhibits cytokine-mediated NF-kappa B activation by blocking a signal leading to IKK activity.
Journal ArticleDOI
Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
TL;DR: The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities as discussed by the authors, and wound healing and detoxifying properties have also received considerable attention.
Journal ArticleDOI
Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin
TL;DR: In this paper, an attempt has been made to test individual curcuminoids such as Curcumin, bisdemethoxycurcumin and demethoxyCurcumin for their antioxidant activities by in vitro model systems, such as the phosphomolybdenum and linoleic acid peroxidation methods.
Journal Article
Chemopreventive Efficacy and Pharmacokinetics of Curcumin in the Min/+ Mouse, a Model of Familial Adenomatous Polyposis
Sarah Perkins,Richard D. Verschoyle,Kirsti A. Hill,Ifat Parveen,Michael D. Threadgill,Ricky A. Sharma,Marion L. Williams,William P. Steward,Andreas J. Gescher +8 more
TL;DR: The comparison of dose, resulting curcumin levels in the intestinal tract, and chemopreventive potency suggests tentatively that a daily dose of 1.6 g ofCurcumin is required for efficacy in humans, and may be useful in theChemoprevention of human intestinal malignancies related to Apc mutations.
References
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Journal ArticleDOI
Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
Journal ArticleDOI
Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.
Journal ArticleDOI
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
TL;DR: In theory, activation could involve (1) heterolysis to OH- and NO2+ (delta rxn Gzero' = 13 kcal/mol at pH 7) or (2) homolysis
Journal ArticleDOI
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
TL;DR: The results collectively indicate that P-450 IIE1 is a major catalyst of the oxidation of benzene, styrene, CCl4, CHCl3, CH2Cl2, CH3Cl, 1,2-dichloropropane, ethylene dichloride, vinyl chloride, vinyl bromide, acrylonitrile, vinyl carbamate, ethylcarbamate, and trichloroethylene.
Journal ArticleDOI
Oxygen radical scavenging activity of curcumin
Elizabeth Kunchandy,M.N.A. Rao +1 more
TL;DR: Curcumin, a potent anti-inflammatory agent, has been studied for its ability to scavenge reactive oxygen radicals which are implicated in inflammation as discussed by the authors, and it has been shown that it is a good scavenger of hydroxyl radical at high concentrations but at low concentrations activated the Fenton system to generate an increased amount of hydrastic radical.
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