Journal ArticleDOI
Damage to rat liver mitochondria promoted by δ-aminolevulinic acid-generated reactive oxygen species: connections with acute intermittent porphyria and lead-poisoning
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The results suggest the involvement of deleterious reactive oxygen species formed at particular mitochondrial sites from transition metal ions and delta-aminolevulinic acid-generated peroxide and/or superoxide species in the pathophysiology of acute intermittent porphyria patients.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-01-03. It has received 153 citations till now. The article focuses on the topics: Superoxide dismutase & Reactive oxygen species.read more
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Mitochondrial damage induced by conditions of oxidative stress
TL;DR: Up to 2% of the oxygen consumed by the mitochondrial respiratory chain undergoes one electron reduction, typically by the semiquinone form of coenzyme Q, to generate the superoxide radical, and subsequently other reactive oxygen species such as hydrogen peroxide and the hydroxyl radical.
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Mitochondrial permeability transition and oxidative stress.
TL;DR: Data is reviewed indicating that MPT is not a consequence of the opening of a pre‐formed pore, but the consequence of oxidative damage to pre‐existing membrane proteins.
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The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.
Stefan W. Ryter,Rex M. Tyrrell +1 more
TL;DR: In this paper, the authors show that the activation of HO-1 is an ubiquitous cellular response to oxidative stress, and that the reaction products of HO activity, biliverdin, and its subsequent metabolite bilirubin, have antioxidant properties.
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5‐Aminolevulinic Acid‐Based Photodynamic Therapy: Principles and Experimental Research
TL;DR: Because PpIX is an efficient photosensitizer, ALA has been introduced as a drug for clinical photodynamic therapy (PDT) of cancer (8,9).
References
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Biochemistry of Oxidative Stress
TL;DR: Diverse biological processes such as inflammation, carcinogenesis, ageing, radiation damage and photobiological effects appear to involve reactive oxygen species, and oxidative stress denotes a shift in the prooxidant/antioxidant balance in favor of the former.
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Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state.
TL;DR: The kinetics for uptake by mitochondria of TPP+ and DDA+ were analyzed, and it was found that TPP+ permeated the mitochondrial membrane about 15 times faster than DDA+.
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The Metabolic Basis of Inherited Diseases
TL;DR: The volume begins with an introduction to molecular genetics and proceeds to establish the utility of the approach to clinical medicine, which has been completely rewritten by knowledgeable authors who write clearly and in concise detail about each subject.
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The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.
Giorgio Minotti,Steven D. Aust +1 more
TL;DR: Using Fe2+, H2O2, and phospholipid liposomes as a model system, it is found that lipid peroxidation, as assessed by malondialdehyde formation, is not initiated by the hydroxyl radical, but rather requires Fe3+ and Fe2+.