Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma
Antonio Palumbo,Asher Chanan-Khan,Katja Weisel,Ajay K. Nooka,Tamás Masszi,Meral Beksac,Ivan Spicka,Vania Hungria,Markus Munder,Maria-Victoria Mateos,Tomer M Mark,Ming Qi,Jordan M. Schecter,Himal Amin,Xiang Qin,William Deraedt,Tahamtan Ahmadi,Andrew Spencer,Pieter Sonneveld +18 more
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TLDR
Among patients with relapsed or relapsed and refractory multiple myeloma, daratumumab in combination with bortezomib and dexamethasone resulted in significantly longer progression-free survival than borteonib and DexamethAsone alone and was associated with infusion-related reactions and higher rates of thrombocytopenia and neutropenia.Abstract:
BackgroundDaratumumab, a human IgGκ monoclonal antibody that targets CD38, induces direct and indirect antimyeloma activity and has shown substantial efficacy as monotherapy in heavily pretreated patients with multiple myeloma, as well as in combination with bortezomib in patients with newly diagnosed multiple myeloma. MethodsIn this phase 3 trial, we randomly assigned 498 patients with relapsed or relapsed and refractory multiple myeloma to receive bortezomib (1.3 mg per square meter of body-surface area) and dexamethasone (20 mg) alone (control group) or in combination with daratumumab (16 mg per kilogram of body weight) (daratumumab group). The primary end point was progression-free survival. ResultsA prespecified interim analysis showed that the rate of progression-free survival was significantly higher in the daratumumab group than in the control group; the 12-month rate of progression-free survival was 60.7% in the daratumumab group versus 26.9% in the control group. After a median follow-up period ...read more
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Journal ArticleDOI
Daratumumab in multiple myeloma: experience of the multiple myeloma GIMEMA Lazio group
Federico Vozella,Agostina Siniscalchi,Manuela Rizzo,Tommaso Za,Giusy Antolino,U Coppetelli,Alfonso Piciocchi,Alessandro Andriani,Ombretta Annibali,L. De Rosa,Giuseppe Cimino,G. La Verde,V. De Stefano,Maria Cantonetti,T. Caravita di Toritto,M.T. Petrucci +15 more
TL;DR: Daratumumab (DARA) is a human IgG-K monoclonal antibody targeting CD38 that is approved alone or in combination with bortezomib and dexamethasone for relapsed or refractory MM (RRMM) in patients previously exposed or double-refractory to proteasome inhibitors (PI) and immunomodulatory drugs (IMiDs).
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Real-World Outcome in the pre-CAR-T Era of Myeloma Patients Qualifying for CAR-T Cell Therapy
TL;DR: In this paper, the authors analyzed all subsequent relapsed/refractory myeloma patients treated between 01/2016 (when anti-CD38 treatment was commercially introduced in Switzerland) and 04/2020 at the University Hospital of Bern.
Journal ArticleDOI
A comparison of the efficacy of immunomodulatory-free regimens in relapsed or refractory multiple myeloma: a network meta-analysis
Katja Weisel,Pieter Sonneveld,Andrew Spencer,Meral Beksac,Maria Rizzo,Ying Xin Xu,Kyle Fahrbach,Maren Gaudig,Mary Slavcev,L. Dearden,Annette Lam +10 more
TL;DR: It is suggested that DVd may provide superior clinical outcomes for RRMM patients suitable for IMiD-free regimens, and network meta-analysis showed that daratumumab plus Vd (DVd) provided a significant advantage in prolonging progression-free survival.
Journal ArticleDOI
Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment.
Benjamin Motais,Sandra Charvátová,Zuzana Walek,Matous Hrdinka,Ryszard Smolarczyk,Tomasz Cichoń,Justyna Czapla,Sebastian Giebel,Michal Simicek,Tomas Jelinek,Tereza Sevcikova,Jiří Sobotka,Zdeněk Kořístek,Roman Hájek,Juli R. Bagó +14 more
TL;DR: In this article, a combination therapy of selected and pretreated NK cells with Daratumumab presented tumor volumes 43-fold smaller than control ones, and the combination therapy was refined with CD16 polymorphism donor selection and uncomplicated novel in vitro pretreatment to avoid undesired fratricide.
Journal ArticleDOI
Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?
TL;DR: How mouse models have furthered the authors' understanding of the immune defects caused by MM and enabled immunotherapeutics to progress to clinical trials is discussed, but also the validity of using immunodeficient models for these purposes is questioned.
References
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TL;DR: In this article, the authors proposed a more flexible method to construct discrete sequential boundaries based on the choice of a function, a*(t), which characterizes the rate at which the error level ac is spent.
Journal ArticleDOI
Targeting CD38 with daratumumab monotherapy in multiple myeloma
Henk M. Lokhorst,Torben Plesner,Jacob P. Laubach,Hareth Nahi,Peter Gimsing,Markus Hansson,Monique C. Minnema,Ulrik Lassen,Ulrik Lassen,Jakub Krejcik,Antonio Palumbo,Niels W.C.J. van de Donk,Tahamtan Ahmadi,Imran Khan,Clarissa M. Uhlar,Jianping Wang,A. Kate Sasser,Nedjad Losic,Steen Lisby,Linda Basse,Nikolai Constantin Brun,Paul G. Richardson +21 more
TL;DR: Daratumumab monotherapy had a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma, and no maximum tolerated dose was identified in part 1.
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