Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration.
TLDR
A novel co-delivery system based on TGF-β1 loaded RGD-coupled alginate microspheres encapsulating periodontal ligament stem cells or gingival mesenchymal stem cells (GMSCs) and PDLSCs is developed, suggesting thatRGD-modified alginates encapsulating dental MSCs make a promising candidate for cartilage regeneration.About:
This article is published in Acta Biomaterialia.The article was published on 2013-12-01 and is currently open access. It has received 98 citations till now. The article focuses on the topics: Periodontal ligament stem cells & Mesenchymal stem cell.read more
Citations
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Injectable Stem Cell-Laden Photocrosslinkable Microspheres Fabricated Using Microfluidics for Rapid Generation of Osteogenic Tissue Constructs
Xin Zhao,Xin Zhao,Shen Liu,Lara Yildirimer,Hong Zhao,Ruihua Ding,Huanan Wang,Wenguo Cui,Wenguo Cui,David A. Weitz +9 more
TL;DR: It is found that BMSCs encapsulated in GelMA microspheres show enhanced osteogenesis in vitro and in vivo, associated with a significant increase in mineralization.
Journal ArticleDOI
Advances and challenges in stem cell culture.
TL;DR: This review provides a comprehensive compendium of recent advancements in culturing SCs using 2-D and 3-D techniques involving spheroids, biomaterials, and bioreactors.
Journal ArticleDOI
Biomaterial-based scaffolds – current status and future directions
Tarun Garg,Amit K. Goyal +1 more
TL;DR: In the future, the main focus will be on the development of more patient compliant, sustained and controlled delivery systems against various diseases by modification of polymers, manufacturing technologies as well as carrier systems.
Journal ArticleDOI
Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration
Xiyuan Mao,Ruoyu Cheng,Hongbo Zhang,Jinhong Bae,Liying Cheng,Lu Zhang,Lianfu Deng,Wenguo Cui,Wenguo Cui,Yuguang Zhang,Hélder A. Santos,Xiaoming Sun +11 more
TL;DR: In a random skin flap animal model, the MF‐Lip@PEG is injectable and convenient to deliver into the skin flap, providing excellent anti‐inflammation, anti‐infection, and proneovascularization effects and significantly reducing theSkin flap necrosis rate.
Journal ArticleDOI
Alginate and its application to tissue engineering
TL;DR: Alginate is a polysaccharide of natural origin, which shows outstanding properties of biocompatibility, gel forming ability, non-toxicity, biodegradability and easy to process as mentioned in this paper.
References
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Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
TL;DR: Postnatal human DPSCs are isolated that have the ability to form a dentin/pulp-like complex and are compared with human bone marrow stromal cells, known precursors of osteoblasts.
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Investigation of multipotent postnatal stem cells from human periodontal ligament
Byoung Moo Seo,Masako Miura,Stan Gronthos,P. M. Bartold,Sara Batouli,Jaime S. Brahim,M. F. Young,Pamela Gehron Robey,Cun-Yu Wang,Songtao Shi +9 more
TL;DR: It is suggested that PDL contains stem cells that have the potential to generate cementum/PDL-like tissue in vivo and transplantation of these cells might hold promise as a therapeutic approach for reconstruction of tissues destroyed by periodontal diseases.
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SHED: Stem cells from human exfoliated deciduous teeth
Masako Miura,Stan Gronthos,Mingrui Zhao,Bai Lu,Larry W. Fisher,Pamela Gehron Robey,Songtao Shi +6 more
TL;DR: It is shown that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells, which may be an unexpected unique resource for stem-cell therapies including autologous stem- cell transplantation and tissue engineering.
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Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.
TL;DR: The existence of many new and encouraging biological approaches to cartilage repair justifies the future investment of time and money in this research area, particularly given the extremely high socio-economic importance of such therapeutic strategies in the prevention and treatment of these common joint diseases and traumas.
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Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
Yang Chai,X. Jiang,Yoshihiro Ito,Pablo Bringas,Jun Han,David H. Rowitch,Philippe Soriano,Andrew P. McMahon,Henry M. Sucov +8 more
TL;DR: It is demonstrated, for the first time, that CNC cells contribute to the formation of condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel's cartilage, mandible, the articulating disc of temporomandibular joint and branchial arch nerve ganglia.