Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.
TLDR
Results indicate that desensitization of turkey erythrocyte adenylate cyclase is highly correlated with phosphorylation of the beta-adrenergic receptor and that these events are mediated, at least partially, by cAMP.About:
This article is published in Journal of Biological Chemistry.The article was published on 1984-08-10 and is currently open access. It has received 151 citations till now. The article focuses on the topics: Cyclase activity & Homologous desensitization.read more
Citations
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Molecular mechanisms of receptor desensitization using the β -adrenergic receptor-coupled adenylate cyclase system as a model
TL;DR: New insights into the molecular mechanisms underlying desensitization have emerged from the study of the receptors coupled to the ubiquitous second messenger-generating system adenylate cyclase.
Journal ArticleDOI
Regulation of transmembrane signaling by receptor phosphorylation
TL;DR: The role of phosphorylation in regulating receptor function dramatically extends the range of regulatory control of this important covalent modification.
Journal ArticleDOI
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
TL;DR: The existence of this novel cAMP-independent kinase, which preferentially phosphorylates the agonist-occupied form of the beta-adrenergic receptor, suggests a mechanism that may explain the homologous or agonists-specific form of adenylate cyclase desensitization and suggests a general mechanism for regulation of receptor function.
Journal ArticleDOI
Regulation of neurotransmitter receptor desensitization by protein phosphorylation
Journal ArticleDOI
Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.
TL;DR: It is concluded that low or high concentrations of agonist elicit phosphorylation of beta 2AR on distinct domains, with different implications for the functional coupling of the receptors with effector molecules.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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A Highly Sensitive Adenylate Cyclase Assay
TL;DR: The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies.