Journal ArticleDOI
Design and fabrication of scaffold-based tissue engineering
Jan Henkel,Dietmar W. Hutmacher +1 more
- Vol. 14, pp 171-193
TLDR
How knowledge from developmental biology and collective tissue healing biology can be applied to optimise the design of scaffolds that promote fundamental steps in tissue regeneration by creating a suitable microenvironment is discussed.Abstract:
Scaffold-based tissue engineering approaches have been under investigation for more than 30 years now and many different techniques have been developed in order to engineer various tissues of the body. Some of them have been translated from bench to bedside, yet many are still under intensive examination. Biodegradable scaffolds applied in tissue engineering aim to temporarily substitute for the extracellular matrix and its complex biological functions during the regeneration and/or remodelling period, and are subsequently degraded and replaced by new tissue. We herein discuss how knowledge from developmental biology and collective tissue healing biology can be applied to optimise the design of scaffolds that promote fundamental steps in tissue regeneration by creating a suitable microenvironment. The review focuses on the design and fabrication of scaffolds for bone tissue engineering, yet also highlights general considerations which apply to scaffolds used in any tissue engineering strategy. We then turn to scaffold manufacturing where a plethora of design and fabrication technologies have been applied to process biomaterials into scaffolds for bone tissue engineering and other applications. Each manufacturing technology has its advantages and disadvantages from a processing, material science and biological point of view. We herein review several additive manufacturing technologies, which in the authors' opinion currently are most relevant for scaffold-based bone tissue engineering. We also provide a future outlook on Image-guided Tissue Engineering, Additive Tissue Manufacturing and Guided Tissue Regeneration with respect to tissue engineering in general and bone tissue engineering in particular.read more
Citations
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The return of a forgotten polymer : Polycaprolactone in the 21st century
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years as discussed by the authors.
A review on stereolithography and its applications in biomedical engineering
TL;DR: Stereolithography is a solid freeform technique (SFF) that was introduced in the late 1980s as discussed by the authors, which has the highest fabrication accuracy and an increasing number of materials that can be processed is becoming available.
Journal Article
Biomedical applications of biodegradable polymers
TL;DR: Degradable biomaterials have been investigated for biomedical applications with novel materials constantly being developed to meet new challenges as mentioned in this paper, and a review summarizes the most recent advances in the field over the past four years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.
Book ChapterDOI
Scaffold design and fabrication
TL;DR: The main aim of this chapter is to assist readers in selecting a specific three-dimensional scaffold processing technology by providing information for determining the critical issues.
References
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Journal ArticleDOI
Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
Journal ArticleDOI
Scaffolds in tissue engineering bone and cartilage.
TL;DR: Research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view is reviews from a biodegradable and bioresorbable perspective.
Journal ArticleDOI
Porous scaffold design for tissue engineering
TL;DR: The integration of CTD with SFF to build designer tissue-engineering scaffolds is reviewed and the mechanical properties and tissue regeneration achieved using designer scaffolds are details.
Journal ArticleDOI
The return of a forgotten polymer—Polycaprolactone in the 21st century
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years.