Journal ArticleDOI
Materials design for bone-tissue engineering
TLDR
In this paper, the authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans, and highlight scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone tissue engineering applications in human therapies and disease models.Abstract:
Successful materials design for bone-tissue engineering requires an understanding of the composition and structure of native bone tissue, as well as appropriate selection of biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals and composites. Scalable fabrication technologies that enable control over construct architecture at multiple length scales, including three-dimensional printing and electric-field-assisted techniques, can then be employed to process these biomaterials into suitable forms for bone-tissue engineering. In this Review, we provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans. We outline the materials-design pathway from implementation strategy through selection of materials and fabrication methods to evaluation. Finally, we discuss unmet needs and current challenges in the development of ideal materials for bone-tissue regeneration and highlight emerging strategies in the field. Design of bone-tissue-engineering materials involves consideration of multiple, often conflicting, requirements. This Review discusses these considerations and highlights scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone-tissue-engineering applications in human therapies and disease models.read more
Citations
More filters
Direct writing by way of melt electrospinning
TL;DR: In this paper, a melt electrospun fibers of poly(ϵ-caprolactone) are accurately deposited using an automated stage as the collector, which matches the translation speed of the collector to the speed of a melting jet to establish control over the location of fiber deposition.
Journal ArticleDOI
Scaffold fabrication technologies and structure/function properties in bone tissue engineering
TL;DR: A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided and strategies to improve vascularization potential and immunomodulation are presented.
Journal ArticleDOI
Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.
Wenying Wei,Honglian Dai +1 more
TL;DR: In this paper, the authors highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation, and signaling factor incorporation including bioreactor application.
Journal ArticleDOI
Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion.
TL;DR: The GNRs/nHA hybrid hydrogel was capable of photothermal treatment of postoperative tumors and bone defect repair in a mice model of tibia osteosarcoma and shows great potential in curing bone tumors and provides a new hope for tumor-related bone complex disease.
References
More filters
Journal ArticleDOI
Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
Journal ArticleDOI
Double‐Network Hydrogels with Extremely High Mechanical Strength
Journal ArticleDOI
Recommendations for the characterization of porous solids (Technical Report)
Jean Rouquerol,D. Avnir,C. W. Fairbridge,D. H. Everett,J. M. Haynes,N. Pernicone,J. D. F. Ramsay,Kenneth S. W. Sing,Klaus K. Unger +8 more
TL;DR: In this article, the authors present a tool for the selection and appraisal of the methods of characterization of porous solids, and also give the warnings and guidelines on which the experts generally agree.
Journal ArticleDOI
Bonding mechanisms at the interface of ceramic prosthetic materials
TL;DR: A theoretical model to explain the interfacial bonding is based upon in-vitro studies of glass-ceramic solubility in interfacial hydroxyapatite crystallization mechanisms, compared with in- vivo rat femur implant histology and ultrastructure results.