Journal ArticleDOI
Design, synthesis and evaluation of antiinflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives.
Shashikant V. Bhandari,Kailash G. Bothara,Mayuresh K. Raut,Ajit A. Patil,Aniket P. Sarkate,Vinod Mokale +5 more
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TLDR
Eight new compounds were found to have significant anti-inflammatory activity in the carrageenan induced rat paw oedema model, with significant analgesic activity inThe acetic acid induced writhing model with no ulcerogenicity and showed promising results in histopathology studies.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2008-02-15. It has received 253 citations till now. The article focuses on the topics: Diclofenac Sodium & Diclofenac.read more
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Schiff Bases: A Versatile Pharmacophore
TL;DR: The present review summarizes information on the diverse biological activities and also highlights the recently synthesized numerous Schiff bases as potential bioactive core.
Journal ArticleDOI
A review exploring biological activities of hydrazones.
Garima Verma,Akranth Marella,Mohammad Shaquiquzzaman,Mymoona Akhtar,Mohammad Ali,Mohammad Mumtaz Alam +5 more
TL;DR: This review aims at highlighting the diverse biological activities of hydrazones, an important class of compounds for new drug development.
Journal ArticleDOI
New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents
TL;DR: The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity.
Journal ArticleDOI
Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives
K. F. Ansari,Chhagan Lal +1 more
TL;DR: Some derivatives of benzimidazole were synthesized by nucleophilic substitution of 2-substituted-1H-benzimidZol-1-yl and showed good activity towards Gram-positive bacteria and negligible activity towards gram-negative bacteria.
Journal ArticleDOI
Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents.
Mohammad Shaquiquzzaman,Garima Verma,Akranth Marella,Mymoona Akhter,Wasim Akhtar,Mohemmed Faraz Khan,Sharba Tasneem,Mohammad Mumtaz Alam +7 more
TL;DR: The review here highlights the therapeutic significance of piperazine derivatives, which have made them indispensable anchors for the development of novel therapeutic agents.
References
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Book
Vogel's Textbook of Practical Organic Chemistry
Arthur I. Vogel,Brian S. Furniss +1 more
TL;DR: In this paper, the authors present a method for the synthesis of organic compounds using Spectroscopic methods and Spectral Spectral Methods (SSTM) with a focus on alicyclic and aliphatic compounds.
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Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs
TL;DR: Patients who take NSAIDs have an increased risk of nonspecific ulceration of the small-intestinal mucosa, which is less common than ulcers of the stomach or duodenum, but can lead to life-threatening complications.
Journal ArticleDOI
Cyclooxygenase inhibitors – current status and future prospects
Gerd Dannhardt,Werner Kiefer +1 more
TL;DR: Agents that inhibit COX-2 while sparing COx-1 represent a new attractive therapeutic development and could represent a major advance in the treatment of rheumatoid arthritis and osteoarthritis.
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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
John J. Talley,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Carol M. Koboldt,Jaime L. Masferrer,William E. Perkins,Roland S. Rogers,Alexander F. Shaffer,Yan Y. Zhang,Ben S. Zweifel,Karen Seibert +11 more
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