Journal ArticleDOI
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.
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Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX and thereby helps to design novel potent inhibitors.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2005-04-01. It has received 278 citations till now. The article focuses on the topics: Trolox & Pyrazole.read more
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Book ChapterDOI
Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
Journal ArticleDOI
Visible-Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
TL;DR: This Review compares classical and photocatalytic procedures for selected classes of reactions and highlights their advantages and limitations.
Journal ArticleDOI
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Preetha Anand,Sherin G. Thomas,Ajaikumar B. Kunnumakkara,Chitra Sundaram,Kuzhuvelil B. Harikumar,Bokyung Sung,Sheeja T. Tharakan,Krishna Misra,Indira K. Priyadarsini,Kallikat N. Rajasekharan,Bharat B. Aggarwal +10 more
TL;DR: This review focuses on the status of all these approaches in generating a "super curcumin," a homodimer of feruloylmethane containing a methoxy group and a hydroxyl group, a heptadiene with two Michael acceptors, and an alpha,beta-diketone.
Journal ArticleDOI
Curcumin: Getting Back to the Roots
TL;DR: Interestingly, 6‐gingerol, a natural analog of curcumin derived from the root of ginger (Zingiber officinalis), exhibits a biologic activity profile similar to that ofCurcumin, which is now being used to treat cancer, arthritis, diabetes, Crohn's Disease, cardiovascular diseases, osteoporosis, Alzheimer's disease, psoriasis, and other pathologies.
Journal ArticleDOI
Curcumin—From Molecule to Biological Function
TL;DR: This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.
References
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Protein Data Bank
TL;DR: The protein data bank (PDB), at Brookhaven National Laboratory, is a database containing information on experimentally determined three-dimensional structures of proteins, nucleic acids, and other biological macromolecules, with approximately 9000 entries.
Journal ArticleDOI
Anti-inflammatory drugs and their mechanism of action
John R. Vane,Regina M. Botting +1 more
TL;DR: Selective COX-2 inhibitors may demonstrate new important therapeutic benefits as anticancer agents, as well as in preventing premature labor and perhaps even retarding the progression of Alzheimer's disease.
Journal ArticleDOI
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
TL;DR: The data suggest that boswellic acids are specific, non-redox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its translocation.