Journal ArticleDOI
Curcumin—From Molecule to Biological Function
TLDR
This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.Abstract:
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in curry and gives curry powder its characteristic yellow color. As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard). Turmeric contains the curcuminoids curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Recently, the health properties (neuroprotection, chemo-, and cancer prevention) of curcuminoids have gained increasing attention. Curcuminoids induce endogenous antioxidant defense mechanisms in the organism and have anti-inflammatory activity. Curcuminoids influence gene expression as well as epigenetic mechanisms. Synthetic curcumin analogues also exhibit biological activity. This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.read more
Citations
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The Chemistry of Curcumin: From Extraction to Therapeutic Agent
TL;DR: An overview of different aspects of the unique chemistry research on curcumin will be discussed, which include methods for the extraction from turmeric, laboratory synthesis methods, chemical and photochemical degradation and the chemistry behind its metabolism.
Journal ArticleDOI
Renoprotective effect of the antioxidant curcumin: Recent findings
Joyce Trujillo,Yolanda I. Chirino,Eduardo Molina-Jijón,Ana Cristina Andérica-Romero,Edilia Tapia,José Pedraza-Chaverri +5 more
TL;DR: The information presented in this paper identifies curcumin as a promising renoprotective molecule against renal injury.
Journal ArticleDOI
Bioactivity of dietary polyphenols: The role of metabolites
Simon Vlad Luca,Simon Vlad Luca,Irina Macovei,Alexandra Bujor,Anca Miron,Krystyna Skalicka-Woźniak,Ana Clara Aprotosoaie,Adriana Trifan +7 more
TL;DR: The present work strongly supports the contribution of metabolites to the health benefits of polyphenol, thus offering a better perspective in understanding the role played by dietary polyphenols in human health.
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Protective effect of curcumin against heavy metals-induced liver damage.
TL;DR: Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper, lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.
Journal ArticleDOI
Degradation of Curcumin: From Mechanism to Biological Implications.
TL;DR: It is suggested that the previously unrecognized diversity of its degradation products could be an important factor in explaining the polypharmacology of curcumin.
References
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Journal ArticleDOI
p53 mutations in human cancers
TL;DR: The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues as mentioned in this paper.
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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
TL;DR: Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Journal ArticleDOI
The widespread regulation of microRNA biogenesis, function and decay.
TL;DR: This work has shown that the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein–protein and protein–RNA interactions has an important role in the context-specific functions of miRNAs.
Journal ArticleDOI
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.