Detoxification reactions: relevance to aging.
TLDR
The expression of multiple detoxification enzymes, each with a significant but relatively modest effect on longevity, is coordinately regulated by signaling pathways such as insulin/insulin-like signaling, explaining the large effect of such pathways on life span.About:
This article is published in Ageing Research Reviews.The article was published on 2008-12-01 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Detoxification & Longevity.read more
Citations
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Journal ArticleDOI
Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?
David Gems,Ryan Doonan +1 more
TL;DR: The oxidative damage theory of aging once seemed almost proven, yet recently the buzzards have been assembling in the blue skies above it and new challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones.
Journal ArticleDOI
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices.
TL;DR: The results suggest that the age-related alteration of glial cells in sensory cortical areas can be accelerated by activity‐driven central mechanisms that result from an age‐related loss of peripheral sensitivity.
Journal ArticleDOI
Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration
TL;DR: This review focuses on a coordinated metabolic network-cytosolic signaling, transcriptional regulation, and mitochondrial function-that controls the cellular energy levels and redox status as well as factors which impair this metabolic network during brain aging and neurodegeneration.
Book ChapterDOI
Mitochondria and reactive oxygen species. Which role in physiology and pathology
TL;DR: Oxidative stress is among the major causes of toxicity due to interaction of Reactive Oxygen Species (ROS) with cellular macromolecules and structures and interference with signal transduction pathways, although the underlying mechanisms are not always completely understood.
Journal ArticleDOI
Bats and birds: Exceptional longevity despite high metabolic rates
TL;DR: Findings from large-scale comparative analyses and laboratory studies on a few emerging model species have identified multiple mechanisms for resisting oxidative damage to mitochondrial DNA and cellular structures in both bats and birds.
References
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Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
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Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
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Pleiotropy, natural selection, and the evolution of senescence
TL;DR: August Weismann's theory is subject to a number of criticisms, the most forceful of which are: 1) The fallacy of identifying senescence with mechanical wear, 2) the extreme rarity, in natural populations, of individuals that would be old enough to die of the postulated death-mechanism, 3) the failure of several decades of gerontological research to uncover any deathmechanisms, and 4) the difficulties involved in visualizing how such a feature could be produced
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Mitochondria, Oxidants, and Aging
TL;DR: The evidence is reviewed that both supports and conflicts with the free radical theory of aging and the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging is examined.