Journal ArticleDOI
Pleiotropy, natural selection, and the evolution of senescence
TLDR
August Weismann's theory is subject to a number of criticisms, the most forceful of which are: 1) The fallacy of identifying senescence with mechanical wear, 2) the extreme rarity, in natural populations, of individuals that would be old enough to die of the postulated death-mechanism, 3) the failure of several decades of gerontological research to uncover any deathmechanisms, and 4) the difficulties involved in visualizing how such a feature could be producedAbstract:
A new individual entering a population may be said to have a reproductive probability distribution. The reproductive probability is zero from zygote to reproductive maturity. Later, perhaps shortly...read more
Citations
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Sex differences in human mate preferences: Evolutionary hypotheses tested in 37 cultures
TL;DR: For example, this paper found that females value cues to resource acquisition in potential mates more highly than males, while males valued earning capacity, ambition, industriousness, youth, physical attractiveness, and chastity.
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The evolution of social behavior
TL;DR: For several years the study of social behavior has been undergoing a revolution with far-reaching consequences for the social and biological sciences, partly due to growing acceptance of the evidence that the potency of natural selection is overwhelmingly concentrated at levels no higher than that of the individual.
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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.
Journal ArticleDOI
Broken Limits to Life Expectancy
Jim Oeppen,James W. Vaupel +1 more
TL;DR: The evidence presented in this paper suggests that the apparent leveling off of life expectancy in various countries is an artifact of laggards catching up and leaders falling behind, not a sign that life expectancy is approaching its limit.
Journal ArticleDOI
Trade-offs in life-history evolution
TL;DR: This discussion finds that the genetic structure of a population, in particular the genetic variance-covariance matrix for a set of important life-history traits, reflects the very recent past, describes the present and predicts the near-term future.
References
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Reproduction in the Western Mosquitofish, Gambusia affinis affinis (Baird & Girard), and Its Use in Mosquito Control
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Modes of Selection
TL;DR: It is concluded with Blum (1951) that evolution took the form at first of decreasing mutability and along with this may have occurred the evolution of stable genic association in cells, and mechanisms of exact duplication of the entire system by mitosis.
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Pleiotropic gene action
TL;DR: It has been found early in the history of genetics that the action of a particular gene may not be restricted to one organ, and genes of this type which affect more than one organ system have been called pleiotropic.