Development, activation, and therapeutic potential of thermogenic adipocytes
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TLDR
C cumulative evidence supports an incontestable role of thermogenic fat in influencing systemic metabolism in humans and the future directions of this fast-evolving field are explored.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-01-01 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Adipocyte.read more
Citations
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PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Tobias Kroon,Matthew J. Harms,Stefanie Maurer,Laurianne Bonnet,Ida Alexandersson,Anna Lindblom,Andrea Ahnmark,Daniel Nilsson,Peter Gennemark,Gavin O'Mahony,Victoria Osinski,Coleen A. McNamara,Jeremie Boucher,Jeremie Boucher +13 more
TL;DR: Tesaglitazar-induced browning was associated with increased energy expenditure, enhanced insulin sensitivity, reduced liver steatosis, and an overall improved metabolic profile compared to rosiglitazone and vehicle control groups.
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Peroxisomal regulation of redox homeostasis and adipocyte metabolism.
TL;DR: A framework for understanding redox regulation of peroxisomal functions in adipocytes together with testable hypotheses for developing therapies for obesity and the related metabolic diseases is provided.
Journal ArticleDOI
EoTHINophils: Eosinophils as key players in adipose tissue homeostasis.
TL;DR: Evidence for the role of adipose‐resident eosinophils in local tissue homeostasis, beiging and systemic metabolism is evaluated, highlighting where more research is needed to establish the specific effector functions that adipose eos inophils perform in response to different internal and external cues.
Journal ArticleDOI
Co-Administration of Curcumin and Artepillin C Induces Development of Brown-Like Adipocytes in Association with Local Norepinephrine Production by Alternatively Activated Macrophages in Mice.
Sho Nishikawa,Misa Kamiya,Hiroki Aoyama,Kazuki Yoshimura,Ryo Miyata,Shigenori Kumazawa,Takanori Tsuda +6 more
TL;DR: Co-administration of Cur and ArtC at lower doses is significantly effective to reduce the dose and enhance the formation of brown-like adipocyte formation in mouse iWAT via a unique molecular mechanism.
De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development
Zhiqiang Bai,Dan Xu,Bingbing Yuan,Kinyui Alice Lo,Myeong Jin Yoon,Yen Ching Lim,Marko Knoll,Shuai Chen,Peng Chen,Lei Sun,Juan Rene Alvarez,Nikolai Slavov,Harvey F. Lodish +12 more
TL;DR: In this paper, the authors used RNA-seq to reconstruct de novo transcriptomes of mouse brown, inguinal white, and epididymal white fat and identified ∼1,500 lncRNAs, including 127 BAT-restricted loci induced during differentiation.
References
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Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
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Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
Journal ArticleDOI
Functional brown adipose tissue in healthy adults.
Kirsi A. Virtanen,Martin E. Lidell,Janne Orava,Mikael Heglind,Rickard Westergren,Tarja Niemi,Markku Taittonen,Jukka Laine,Nina-Johanna Savisto,Sven Enerbäck,Pirjo Nuutila +10 more
TL;DR: These findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.