Journal ArticleDOI
Development of a polymer stent with shape memory effect as a drug delivery system.
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TLDR
The shape memory properties of thermoplastic polyurethane allow to design a new fully polymeric self-expandable stent for the drug delivery application.Abstract:
The article presents a new concept for vascular endoprothesis (stent). Almost all commercially available stents are made of metallic materials. A common after effect of stent implantation is restenosis. Several studies on metal stents coated with drug show, that the use of a drug delivery system may reduce restenosis. The purpose of this work is to develop a new stent for the drug delivery application. The shape memory properties of thermoplastic polyurethane allow to design a new fully polymeric self-expandable stent. The possibility to use the stent as a drug delivery system is described.read more
Citations
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Journal ArticleDOI
Shape-memory polymers
Marc Behl,Andreas Lendlein +1 more
TL;DR: Shape-memory polymers as discussed by the authors are an emerging class of active polymers that can change their shape in a predefined way from shape A to shape B when exposed to an appropriate stimulus.
Journal ArticleDOI
Shape-memory polymers and their composites: Stimulus methods and applications
TL;DR: Shape-memory polymers (SMPs) undergo significant macroscopic deformation upon the application of an external stimulus (e.g., heat, electricity, light, magnetism, moisture and even a change in pH value).
Journal ArticleDOI
Recent advances in shape–memory polymers: Structure, mechanism, functionality, modeling and applications
TL;DR: In this paper, a comprehensive review of shape-memory polymers (SMPs) and their derivatives, such as composites and compound structures, as well as their current applications are presented.
Journal ArticleDOI
Recent advances in shape memory polymers and composites : a review
TL;DR: Shape memory polymers (SMPs) belong to a class of smart polymers, which have drawn considerable research interest in recent years because of their applications in microelectromechanical systems, actuators, for self healing and health monitoring purposes, and in biomedical devices as mentioned in this paper.
Journal ArticleDOI
Stimulus-responsive shape memory materials: A review
TL;DR: A brief review on the current progress in stimuli-responsive shape memory materials can be found in this article, where the focus is on twofold, namely newly observed ones, and novel applications with great potential at present and in near future.
References
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Journal ArticleDOI
Polyurethanes having shape memory effects
TL;DR: In this paper, the effects of soft segment molecular weight (Mn = 2000, 4000 and 8000), soft segment content (50-90%), and maximum strain (em = 100, 200, and 600%) on the cyclic tensile properties as well as the dynamic mechanical, and mechanical properties below (25°C) and above (65°C), were studied.
Journal ArticleDOI
In vitro analyses of diamond-like carbon coated stents. Reduction of metal ion release, platelet activation, and thrombogenicity.
TL;DR: Coating of intracoronary stents with diamond-like carbon significantly improves biocompatibility and may contribute to a reduction in thrombogenicity.
Journal ArticleDOI
Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries.
Deirdre M. Whelan,W.J. van der Giessen,S. Krabbendam,E A van Vliet,P. D. Verdouw,P. W. Serruys,H.M.M. van Beusekom +6 more
TL;DR: In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting.
Journal ArticleDOI
Experimental Study of Thrombogenicity and Foreign Body Reaction Induced by Heparin-Coated Coronary Stents
Ivan De Scheerder,Kai Wang,Krzysztof Wilczek,Dirk G. Meuleman,Ronald Van Amsterdam,G.M.T. Vogel,Jan Piessens,Frans Van de Werf +7 more
TL;DR: Hemarin coating of metallic coronary stents decreases their thrombogenicity but does not improve late vessel patency and neointimal hyperplasia at follow-up in a porcine coronary model.
Journal ArticleDOI
Shape memory polyurethane containing mesogenic moiety
TL;DR: The shape memory effect of TPUs synthesized from diol-terminated poly(caprolactone) (PCL diol), 4,4′-diphenylmethane diisocyanate (MDI), and mesogenic chain extenders, such as 4, 4′-bis-(2-hydroxyethoxy)biphexyl (BEBP) or BHBP, was examined and compared with results for PCL diol/MDI/1,4-butanediol (BD) in a previous study
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Biodegradable, Elastic Shape Memory Polymers for Potential Biomedical Applications
Andreas Lendlein,Robert Langer +1 more