Development of an ovarian cancer symptom index
Barbara A. Goff,Barbara A. Goff,Lynn S. Mandel,Lynn S. Mandel,Charles W. Drescher,Nicole Urban,Nicole Urban,Shirley Gough,Kristi M. Schurman,Joshua Patras,Barry S. Mahony,M. Robyn Andersen,M. Robyn Andersen +12 more
TLDR
Currently, screening for ovarian cancer is not recommended for the general population, but targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity.Abstract:
BACKGROUND.
Currently, screening for ovarian cancer is not recommended for the general population. Targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity.
METHODS.
A case-control study of 149 women with ovarian cancer, including 255 women who were in a screening program and 233 women who were referred for pelvic/abdominal ultrasound, was conducted by inviting women to complete a survey of symptoms. Patients were divided randomly into an exploratory group and a confirmatory group. Symptom types, frequency, severity, and duration were compared between cases and controls. Logistic regression analyses were used to determine which factors independently predicted cancer in the exploratory group and then were used to develop a symptom index, which was tested for sensitivity and specificity in the confirmatory group.
RESULTS.
Symptoms that were associated significantly with ovarian cancer were pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, and difficulty eating/feeling full when they were present for 12 days per month. In a logistic regression analysis, symptoms that were associated independently with cancer were pelvic/abdominal pain (P 12 times per month but were present for 50 years and 86.7% for women age <50 years.
CONCLUSIONS.
Specific symptoms in conjunction with their frequency and duration were useful in identifying women with ovarian cancer. A symptom index may be useful for identifying women who are at risk. Cancer 2007. © 2006 American Cancer Society.read more
Citations
More filters
Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines
TL;DR: Lymphedema is a common complication after treatment for breast cancer and factors associated with increased risk of lymphedEMA include extent of axillary surgery, axillary radiation, infection, and patient obesity.
Journal ArticleDOI
Recent progress in the diagnosis and treatment of ovarian cancer.
TL;DR: New targeted biologic agents, particularly those involved with the vascular endothelial growth factor pathway and those targeting the poly (ADP‐ribose) polymerase (PARP) enzyme, hold great promise for improving the outcome of ovarian cancer.
Journal ArticleDOI
Epithelial ovarian cancer.
TL;DR: Pithelial ovarian cancer is the deadliest gynecologic malignancy in women, constituting the fourth most common cause of death in women and the fifth most common among United States women, after cancers of the lung, breast, colon, and uterus.
Journal ArticleDOI
Clinical practice. Screening for ovarian cancer.
TL;DR: A 56-year-old woman presents to her physician, requesting screening for ovarian cancer, after the recent death of a friend from ovarian cancer at the age of 65 years, and the physical examination is normal.
References
More filters
Journal ArticleDOI
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
Journal ArticleDOI
Development and validation of brief measures of positive and negative affect: The PANAS scales.
TL;DR: Two 10-item mood scales that comprise the Positive and Negative Affect Schedule (PANAS) are developed and are shown to be highly internally consistent, largely uncorrelated, and stable at appropriate levels over a 2-month time period.
Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Journal ArticleDOI
Cancer statistics, 2006.
Ahmedin Jemal,Rebecca L. Siegel,Elizabeth Ward,Taylor Murray,Jiaquan Xu,Carol Smigal,Michael J. Thun +6 more
TL;DR: The American Cancer Society estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from National Center for Health Statistics as discussed by the authors.
Journal Article
The task force.
TL;DR: The Joint UNECE/Eurostat/OECD Working Group on Statistics for Sustainable Development (WGSSD) was commissioned by the CES in 2005 to develop a broad conceptual framework for measuring sustainable development based on the capital approach, and to identify a small set of indicators that could serve for international comparisons.
Related Papers (5)
Frequency of Symptoms of Ovarian Cancer in Women Presenting to Primary Care Clinics
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: Results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
Usha Menon,Aleksandra Gentry-Maharaj,Rachel Hallett,Andy Ryan,Matthew Burnell,A. Sharma,Sara Lewis,Susan Davies,Susan Philpott,Alberto Lopes,Keith M. Godfrey,David H. Oram,Jonathan Herod,Karin Williamson,Mourad W Seif,Ian A Scott,Tim Mould,Robert Woolas,John Murdoch,Stephen Dobbs,Nazar Najib Amso,Simon Leeson,Derek Cruickshank,Alistair McGuire,Stuart Campbell,Lesley Fallowfield,Naveena Singh,Anne Dawnay,Steven J. Skates,Mahesh K. B. Parmar,Ian Jacobs +30 more
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.
Saundra S. Buys,Edward E. Partridge,Amanda Black,Christine Cole Johnson,Lois Lamerato,Claudine Isaacs,Douglas J. Reding,Robert T. Greenlee,Lance A. Yokochi,Bruce Kessel,E. David Crawford,Timothy R. Church,Gerald L. Andriole,Joel L. Weissfeld,Mona N. Fouad,David Chia,Barbara O'Brien,Lawrence R. Ragard,Jonathan D. Clapp,Joshua M. Rathmell,Thomas L. Riley,Patricia Hartge,Paul F. Pinsky,Claire S. Zhu,Grant Izmirlian,Barnett S. Kramer,Anthony B. Miller,Jian Lun Xu,Philip C. Prorok,John K. Gohagan,Christine D. Berg +30 more