Journal ArticleDOI
Development of Oil-in-Gelatin Phantoms for Viscoelasticity Measurement in Ultrasound Shear Wave Elastography
TLDR
The results indicate that adding castor oil to gelatin phantoms decreases shear modulus, but increases shear wave dispersion, and the phantom recipe developed in this study can be used in validating ultrasound shearWave elastography techniques for soft tissues.Abstract:
Because tissues consist of solid and fluid materials, their mechanical properties should be characterized in terms of both elasticity and viscosity. Although the elastic properties of tissue-mimicking phantoms have been extensively studied and well characterized in commercially available phantoms, their viscous properties have not been fully investigated. In this article, a set of 14 tissue-mimicking phantoms with different concentrations of gelatin and castor oil were fabricated and characterized in terms of acoustic and viscoelastic properties. The results indicate that adding castor oil to gelatin phantoms decreases shear modulus, but increases shear wave dispersion. For 3% gelatin phantoms containing 0%, 10%, 20% and 40% oil, the measured shear moduli are 2.01 ± 0.26, 1.68 ± 0.25, 1.10 ± 0.22 and 0.88 ± 0.17 kPa, and the Voigt-model coupled shear viscosities are 0.60 ± 0.11, 0.89 ± 0.07, 1.05 ± 0.11 and 1.06 ± 0.13 Pa·s, respectively. The results also confirm that increasing the gelatin concentration increases shear modulus. For phantoms containing 3%, 4%, 5%, 6% and 7% gelatin, the measured shear moduli are 2.01 ± 0.26, 3.10 ± 0.34, 4.18 ± 0.84, 8.05 ± 1.00 and 10.24 ± 1.80 kPa at 0% oil and 1.10 ± 0.22, 1.97 ± 0.20, 3.13 ± 0.63, 4.60 ± 0.60 and 8.43 ± 1.39 kPa at 20% oil, respectively. The phantom recipe developed in this study can be used in validating ultrasound shear wave elastography techniques for soft tissues.read more
Citations
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Journal ArticleDOI
Anisotropic polyvinyl alcohol hydrogel phantom for shear wave elastography in fibrous biological soft tissue: a multimodality characterization
Simon Chatelin,Miguel Bernal,Thomas Deffieux,Clement Papadacci,Patrice Flaud,Amir Nahas,Claude Boccara,Jean-Luc Gennisson,Mickael Tanter,Mathieu Pernot +9 more
TL;DR: The results suggest that this type of phantom (TI) could be used in the development of techniques and equipment to study anisotropy, such as the design of new ultrasound probes for cardiac and musculoskeletal application.
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Improved forward model for quantitative pulse-echo speed-of-sound imaging.
TL;DR: In this article, the phase shift is detected between pairs of Tx and Rx angles that are centred around a set of common mid-angles, and an additional phase shift induced by the offset of the reconstructed position of echoes.
Journal ArticleDOI
Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves
TL;DR: Mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue viscoelastic properties using magnetomotive optical coherence elastography and the extraction of the complex shear modulus is demonstrated.
Journal ArticleDOI
Polyvinyl chloride as a multimodal tissue-mimicking material with tuned mechanical and medical imaging properties.
Weisi Li,Barry Belmont,Joan M. Greve,Adam B. Manders,Brian C. Downey,Xi Zhang,Zhen Xu,Dongming Guo,Albert J. Shih +8 more
TL;DR: A regression model was built to describe the relationship between the mechanical and medical imaging properties and the values of the three composition factors of PVC and can be used to design soft PVC with targeted mechanical andmedical imaging properties.
Journal ArticleDOI
The role of viscosity estimation for oil-in-gelatin phantom in shear wave based ultrasound elastography.
Ying Zhu,Changfeng Dong,Yin Yin,Xin Chen,Yanrong Guo,Yi Zheng,Yuanyuan Shen,Tianfu Wang,Xinyu Zhang,Siping Chen +9 more
TL;DR: Two shear wave-based elasticity imaging methods were compared and the role of viscosity was investigated, demonstrating that adding castor oil changed the viscoelastic properties of the phantoms and resulted in increased dispersion of the shear waves.
References
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Journal ArticleDOI
Supersonic shear imaging: a new technique for soft tissue elasticity mapping
TL;DR: The first in vivo investigations made on healthy volunteers emphasize the potential clinical applicability of SSI for breast cancer detection and results validating SSI in heterogeneous phantoms are presented.
Journal ArticleDOI
Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
Juliette Foucher,E. Chanteloup,J. Vergniol,Laurent Castera,B. Le Bail,Xavier Adhoute,J. Bertet,Patrice Couzigou,V. de Ledinghen +8 more
TL;DR: Transient elastography is a promising non-invasive method for detection of cirrhosis in patients with chronic liver disease and its use for the follow up and management of these patients could be of great interest and should be evaluated further.
Journal ArticleDOI
Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography
Meng Yin,Jayant A. Talwalkar,Kevin J. Glaser,Armando Manduca,Roger C. Grimm,Phillip J. Rossman,Jeff L. Fidler,Richard L. Ehman +7 more
TL;DR: MR elastography is a safe, noninvasive technique with excellent diagnostic accuracy for assessing liver fibrosis and an initial clinical application may be to triage patients who are under consideration for biopsy examination to assess possible hepatic fibrosis.
Journal ArticleDOI
Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging.
Mickael Tanter,Jeremy Bercoff,A. Athanasiou,Thomas Deffieux,Jean-Luc Gennisson,Gabriel Montaldo,Marie Muller,Anne Tardivon,Mathias Fink +8 more
TL;DR: Preliminary clinical results directly demonstrate the clinical feasibility of this new elastography technique in providing quantitative assessment of relative stiffness of breast tissues and give valuable information that is complementary to the B-mode morphologic information.
Journal ArticleDOI
Quantifying hepatic shear modulus in vivo using acoustic radiation force.
TL;DR: Simulation and in vivo data to date demonstrate that this algorithm to quantify shear wave speed from radiation force-induced, ultrasonically-detected displacement data that is robust in the presence of poor displacement signal-to-noise ratio appears promising as a clinical tool for quantifying liver stiffness.