Journal ArticleDOI
Development of the asthma control test: A survey for assessing asthma control
Robert A. Nathan,Christine A. Sorkness,Mark Kosinski,Michael Schatz,James T.C. Li,Philip Marcus,John J. Murray,T.B. Pendergraft +7 more
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TLDR
Results reinforce the usefulness of a brief, easy to administer, patient-based index of asthma control.Abstract:
Background Asthma guidelines indicate that the goal of treatment should be optimum asthma control In a busy clinic practice with limited time and resources, there is need for a simple method for assessing asthma control with or without lung function testing Objectives The objective of this article was to describe the development of the Asthma Control Test (ACT), a patient-based tool for identifying patients with poorly controlled asthma Methods A 22-item survey was administered to 471 patients with asthma in the offices of asthma specialists The specialist's rating of asthma control after spirometry was also collected Stepwise regression methods were used to select a subset of items that showed the greatest discriminant validity in relation to the specialist's rating of asthma control Internal consistency reliability was computed, and discriminant validity tests were conducted for ACT scale scores The performance of ACT was investigated by using logistic regression methods and receiver operating characteristic analyses Results Five items were selected from regression analyses The internal consistency reliability of the 5-item ACT scale was 084 ACT scale scores discriminated between groups of patients differing in the specialist's rating of asthma control (F = 345, P P 1 (F = 43, P = 0052) As a screening tool, the overall agreement between ACT and the specialist's rating ranged from 71% to 78% depending on the cut points used, and the area under the receiver operating characteristic curve was 077 Conclusion Results reinforce the usefulness of a brief, easy to administer, patient-based index of asthma controlread more
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Journal ArticleDOI
The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study.
Oliver Fuchs,Thomas Bahmer,Markus Weckmann,Anna-Maria Dittrich,Bianca Schaub,Barbara Rösler,Christine Happle,Folke Brinkmann,Folke Brinkmann,Isabell Ricklefs,Inke R. König,Henrik Watz,Klaus F. Rabe,Matthias V. Kopp,Gesine Hansen,Erika von Mutius +15 more
TL;DR: AllIANCE offers a unique, integrative and inter-disciplinary framework with a comprehensive molecular approach in a prospective and identical fashion across ages in order to identify biomarkers and predictors for distinct childhood wheeze and asthma trajectories as well as their further course during adulthood.
Book ChapterDOI
Management of asthma: the current US and European guidelines.
Ashwini Reddy,Meera Gupta +1 more
TL;DR: This chapter summarizes the evolution of asthma management guidelines and summarizes the key points and evidence used in the recommendations for the assessment, monitoring, and management of asthma in all ages, with particular emphasis on the NHLBI guidelines.
Journal ArticleDOI
Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease.
Micheál Mac Aogáin,Kenny J. X. Lau,Zhao Cai,Jayanth Kumar Narayana,Rikky W. Purbojati,Daniela I. Drautz-Moses,Nicolas E. Gaultier,Tavleen Kaur Jaggi,Pei Yee Tiew,Thun How Ong,Mariko Siyue Koh,Albert Lim Yick Hou,John Abisheganaden,Krasimira Tsaneva-Atanasova,Stephan C. Schuster,Sanjay H. Chotirmall +15 more
TL;DR: A “core” airway resistome dominated by macrolide but with high prevalence of β-lactam, fluoroquinolone, and tetracycline resistance genes exists and is independent of disease status or antibiotic exposure.
Journal ArticleDOI
A repeated short educational intervention improves asthma control and quality of life
Vicente Plaza,Meritxell Peiro,Montserrat Torrejón,Monica Fletcher,Antolín López-Viña,José María Ignacio,José Antonio Quintano,Santiago Bardagí,Ignasi Gich +8 more
TL;DR: The AEP-RSI was effective in improving asthma symptom control, future risk and quality of life.
Journal ArticleDOI
Does asthma control correlate with quality of life related to upper and lower airways? A real life study.
Fulvio Braido,Ilaria Baiardini,Sara Balestracci,V Ghiglione,E. Stagi,Erminia Ridolo,R. Nathan,Giorgio Walter Canonica +7 more
TL;DR: The relationship between asthma control, impact of comorbid rhinitis and health related quality of life (HRQoL) in real life remains unexplored.
References
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TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
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Journal ArticleDOI
Development and validation of a questionnaire to measure asthma control
TL;DR: The Asthma Control Questionnaire has strong evaluative and discriminative properties and can be used with confidence to measure asthma control.
Journal Article
Surveillance for asthma--United States, 1980-1999.
David M. Mannino,David M. Homa,Lara J. Akinbami,Jeanne E. Moorman,Charon Gwynn,Stephen C. Redd +5 more
TL;DR: In this paper, the authors present national data regarding self-reported asthma prevalence, school and work days lost because of asthma, and asthma-associated activity limitations (1980-1996); asthmaassociated outpatient visits, asthmaassociated hospitalizations, asthma associated hospitalizations and asthmaassociated deaths.
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