Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study
Georg Schett,A. Kleyer,Carlo Perricone,Enijad Sahinbegovic,Annamaria Iagnocco,Jochen Zwerina,Rolando Lorenzini,Franz Aschenbrenner,Francis Berenbaum,Maria Antonietta D'Agostino,Johann Willeit,Stefan Kiechl +11 more
Reads0
Chats0
TLDR
Type 2 diabetes predicts the development of severe OA independent of age and BMI, and the findings strengthen the concept of a strong metabolic component in the pathogenesis of OA.Abstract:
OBJECTIVE To evaluate if type 2 diabetes is an independent risk predictor for severe osteoarthritis (OA). RESEARCH DESIGN AND METHODS Population-based cohort study with an age- and sex-stratified random sample of 927 men and women aged 40–80 years and followed over 20 years (1990–2010). RESULTS Rates of arthroplasty (95% CI) were 17.7 (9.4–30.2) per 1,000 person-years in patients with type 2 diabetes and 5.3 (4.1–6.6) per 1,000 person-years in those without ( P P P = 0.023) after adjustment for age, BMI, and other risk factors for OA. The probability of arthroplasty increased with disease duration of type 2 diabetes and applied to men and women, as well as subgroups according to age and BMI. Our findings were corroborated in cross-sectional evaluation by more severe clinical symptoms of OA and structural joint changes in subjects with type 2 diabetes compared with those without type 2 diabetes. CONCLUSIONS Type 2 diabetes predicts the development of severe OA independent of age and BMI. Our findings strengthen the concept of a strong metabolic component in the pathogenesis of OA.read more
Citations
More filters
Journal ArticleDOI
Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis
TL;DR: A high frequency of OA in patients with DM and an association between both diseases is highlighted, representing a further step towards the individualisation of DM-related OA within a metabolic OA phenotype.
Journal ArticleDOI
Is osteoarthritis a metabolic disease
Jérémie Sellam,Francis Berenbaum +1 more
TL;DR: Osteoarthritis is emerging as a disease that has a variety of phenotypes including a metabolic phenotype, in addition to the age-related and injury-related phenotypes.
Journal ArticleDOI
Metabolic stress-induced joint inflammation and osteoarthritis.
TL;DR: In this paper, a review discusses hypotheses based on pathways specific to a metabolic factor in MetS-associated OA, such as the role of advanced glycation end products and glucose toxicity.
Journal ArticleDOI
Diabetes is a risk factor for knee osteoarthritis progression.
F. Eymard,Camille Parsons,Mark H. Edwards,F Petit-Dop,Jean-Yves Reginster,Olivier Bruyère,Pascal Richette,Cyrus Cooper,Xavier Chevalier +8 more
TL;DR: Type 2 diabetes was a predictor of joint space reduction in men with established knee OA and no relationships were found between MetS or other metabolic factors and radiographic progression.
Journal ArticleDOI
Review: Metabolic Regulation of Inflammation in Osteoarthritis.
TL;DR: Osteoarthritis has long been considered the unique consequence of a tear and wear process leading to cartilage degradation as discussed by the authors, with the production of osteophytes being considered a reactive process of the bone to protect and stabilize the altered joint.
References
More filters
Journal ArticleDOI
Report of the expert committee on the diagnosis and classification of diabetes mellitus
James R. Gavin,K. G M M Alberti,Mayer B. Davidson,Ralph A. DeFronzo,Allan Drash,Steven G. Gabbe,Saul M. Genuth,Maureen I. Harris,Richard Kahn,Harry Keen,William C. Knowler,Harold E. Lebovitz,Noel K. Maclaren,Jerry P. Palmer,Philip Raskin,Robert A. Rizza,Michael P. Stern +16 more
TL;DR: It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease.
Journal ArticleDOI
Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
Roy D. Altman,E. Asch,Daniel Bloch,Giles G. Bole,David G. Borenstein,Kenneth D. Brandt,Wallace C. Christy,Cooke Td,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,David L. Kaplan,William J. Koopman,Selden Longley,Henry J. Mankin,Dennis J. McShane,Thomas A. Medsger,Robert F. Meenan,William M. Mikkelsen,Roland W. Moskowitz,William A. Murphy,B. Rothschild,Mark R. Segal,Leon Sokoloff,Frederick Wolfe +24 more
TL;DR: Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop sets of criteria that serve different investigative purposes and these proposed criteria utilize classification trees, or algorithms.
Journal ArticleDOI
Standards of Medical Care in Diabetes—2010
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care.
Journal ArticleDOI
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.
Roy D. Altman,Graciela S. Alarcón,D. Appelrouth,Daniel Bloch,David G. Borenstein,Kenneth D. Brandt,C. Brown,Cooke Td,W W Daniel,D. Feldman,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,Robert W. Ike,P. Kapila,David L. Kaplan,William J. Koopman,Catherine Marino,Eric V. McDonald,Dennis J. McShane,Thomas A. Medsger,B. A. Michel,William A. Murphy,T. Osial,Rosalind Ramsey-Goldman,Bruce M. Rothschild,Frederick Wolfe +26 more
TL;DR: Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis of the hands were developed from data collected in a multicenter study and required that at least 3 of these 4 criteria be present to classify a patient as having OA of the hand.
Journal ArticleDOI
Diabetes mellitus, fasting glucose, and risk of cause-specific death.
Sreenivasa Rao Kondapally Seshasai,Stephen Kaptoge,Alexander J. Thompson,Emanuele Di Angelantonio,Pei Gao,Nadeem Sarwar,Peter H. Whincup,Kenneth J. Mukamal,Richard F. Gillum,Ingar Holme,Inger Njølstad,Astrid E. Fletcher,Peter M. Nilsson,Sarah Lewington,Rory Collins,Vilmundur Gudnason,Simon G. Thompson,Naveed Sattar,Elizabeth Selvin,Frank B. Hu,John Danesh +20 more
TL;DR: In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors.