Journal ArticleDOI
Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology.
Toru Nawa,Jun Kato,Hirofumi Kawamoto,Hiroyuki Okada,Hiroshi Yamamoto,Hiroyuki Kohno,Hisayuki Endo,Yasushi Shiratori +7 more
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TLDR
The clinical and biological differences between right‐ and left‐sided colon cancers have been widely debated, but close analyses of these clinical differences, based on large‐scale studies, have been scarcely reported.Abstract:
Background and Aim: Recently, the clinical and biological differences between right- and left-sided colon cancers have been widely debated. However, close analyses of these clinical differences, based on large-scale studies, have been scarcely reported.
Methods: A total of 3552 consecutive Japanese colorectal cancer cases were examined and the clinical differences between right- and left-sided colon cancer cases were investigated.
Results: The proportion of right-sided colon cancer was relatively high in patients aged less than 40 years (33%) and more than 80 years (43%). The proportion of right-sided colon cancer in patients aged 40–59 years was relatively low (male 22% and female 29%). In male patients the proportion increased in the 70-79 years age group (30%), while in female patients the proportion increased in the 60-69 years age group (39%). Right-sided colon cancer was more likely to be detected at an advanced stage (T1 stage; left 22%, right 15%) (P < 0.01) with severe symptoms. Polypoid-type early cancer was dominant in the left colon (left 59%; right 40%) (P < 0.01), while the proportion of flat-type early cancer in the right colon was significantly higher than that in the left colon (left 25%; right 44%) (P < 0.01).
Conclusions: Specific age distribution of right-sided colon cancer was observed and the difference between male and female patients was highlighted. Other clinical features also differed between right- and left-sided colon cancer, suggesting that different mechanisms may be at work during right and left colon carcinogenesis.read more
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Journal ArticleDOI
Colorectal cancer statistics, 2017.
Rebecca L. Siegel,Kimberly D. Miller,Stacey A. Fedewa,Dennis J. Ahnen,Reinier G.S. Meester,Afsaneh Barzi,Ahmedin Jemal +6 more
TL;DR: Overall CRC incidence in individuals ages ≥50 years declined from 2009 to 2013 in every state except Arkansas, with the decrease exceeding 5% annually in 7 states; however, rectal tumor incidence in those ages 50 to 64 years was stable in most states.
Journal ArticleDOI
Colorectal cancer statistics, 2020.
Rebecca L. Siegel,Kimberly D. Miller,Ann Goding Sauer,Stacey A. Fedewa,Lynn F. Butterly,Lynn F. Butterly,Joseph C. Anderson,Joseph C. Anderson,Andrea Cercek,Robert A. Smith,Ahmedin Jemal +10 more
TL;DR: Progress against CRC can be accelerated by increasing access to guideline‐recommended screening and high‐quality treatment, particularly among Alaska Natives, and elucidating causes for rising incidence in young and middle‐aged adults.
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Colorectal cancer statistics, 2014
TL;DR: Progress in reducing colorectal cancer death rates can be accelerated by improving access to and use of screening and standard treatment in all populations, including the most current data on incidence, survival, and mortality rates and trends.
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Protection From Colorectal Cancer After Colonoscopy: A Population-Based, Case–Control Study
Hermann Brenner,Jenny Chang-Claude,Christoph M. Seiler,Alexander Rickert,Michael Hoffmeister +4 more
TL;DR: In this paper, the authors assessed the association between previous colonoscopy and risk for colorectal cancer (CRC) in a population-based case-control study.
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Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies.
TL;DR: Compelling and consistent evidence from randomised controlled trials and observational studies suggests that screening sigmoidoscopy and screening colonoscopy prevent most deaths from distal colorectal cancer.
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Hereditary Colorectal Cancer
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Journal ArticleDOI
Are there two sides to colorectal cancer
TL;DR: Differences between normal right and left colonic segments that could favour progression through different tumourigenic pathways are summarized in this review and the existence of 2 broadly different groups of cancer defined by site of origin in the colon should be considered.
Journal ArticleDOI
Meat consumption and risk of colorectal cancer.
Ann Chao,Michael J. Thun,Cari J. Connell,Marjorie L. McCullough,Eric J. Jacobs,W. Dana Flanders,Carmen Rodriguez,Rashmi Sinha,Eugenia E. Calle +8 more
TL;DR: The results demonstrate the potential value of examining long-term meat consumption in assessing cancer risk and strengthen the evidence that prolonged high consumption of red and processed meat may increase the risk of cancer in the distal portion of the large intestine.