Journal ArticleDOI
Differences in Awareness of Pre-exposure Prophylaxis and Post-exposure Prophylaxis Among Groups At-Risk for HIV in New York State: New York City and Long Island, NY, 2011-2013.
Suzan M. Walters,Alexis V. Rivera,Lila Starbuck,Kathleen H. Reilly,Nyasha Boldon,Bridget J. Anderson,Sarah L. Braunstein +6 more
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TLDR
Large proportions of groups at-risk for HIV were unaware of PrEP/PEP and the findings suggest that awareness may be spreading through networks and highlight the importance of targeted educational and prevention efforts by group and region.Abstract:
Background Pre-exposure prophylaxis (PrEP) to reduce the risk of HIV was approved in 2012 and post-exposure prophylaxis (PEP) in 2005. We report the differences in awareness of PrEP/PEP and factors associated with awareness by examining 3 risk groups (men who have sex with men (MSM), people who inject drugs, and high-risk heterosexuals). Methods National HIV Behavioral Surveillance system data collected in New York City (NYC) and Long Island, NY in 2011-2013 were used. Logistic regressions by region were developed to estimate adjusted associations [Adjusted Odds Ratios (AOR)] and determine differences in awareness of PrEP/PEP. Results Awareness of PrEP/PEP was low for all groups. In multivariate analysis controlling for sociodemographic factors, noninjection drug use, HIV status, and exposure to HIV prevention, males who inject drugs in NYC had significantly decreased odds of PrEP/PEP awareness [AOR: 0.45; confidence interval (CI): 0.25 to 0.81] compared with MSM. MSM aged 18-29 years had increased awareness of PrEP (AOR: 2.94; 95% CI 1.11 to 7.80). On Long Island, females who inject drugs (AOR: 0.18; 95% CI: 0.05 to 0.62), males who inject drugs (AOR: 0.14; 95% CI: 0.05 to 0.39), female heterosexuals (AOR: 0.25; 95% CI: 0.11 to 0.59), and male heterosexuals (AOR: 0.32; 95% CI: 0.14 to 0.73) had significantly decreased odds of PrEP/PEP awareness. Black MSM had increased awareness of PrEP (AOR: 4.08 CI:1.21 to 13.73). Conclusions Large proportions of groups at-risk for HIV were unaware of PrEP/PEP. When comparing risk groups to MSM, we found MSM to have greater awareness in both regions. On Long Island, people who inject drugs and heterosexuals were far less likely to have PrEP/PEP awareness than in NYC. On Long Island, Black MSM had increased PrEP awareness and in NYC MSM aged 18-29 had increased PrEP awareness. These findings suggest that awareness may be spreading through networks and highlight the importance of targeted educational and prevention efforts by group and region.read more
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Journal ArticleDOI
Perspectives on HIV pre-exposure prophylaxis (PrEP) utilization and related intervention needs among people who inject drugs.
Katie B. Biello,Katie B. Biello,Angela R. Bazzi,Matthew J. Mimiaga,Dea L. Biancarelli,Alberto Edeza,Peter Salhaney,Ellen Childs,Mari-Lynn Drainoni +8 more
TL;DR: A qualitative study in the Northeastern USA, where recent clusters of new HIV infections have been attributed to injection drug use, identifies multilevel barriers to PrEP use among HIV-uninfected PWID and related intervention strategies and proposes additional intervention targets.
Journal ArticleDOI
PrEP awareness, eligibility, and interest among people who inject drugs in Baltimore, Maryland.
Susan G. Sherman,Kristin E. Schneider,Ju Nyeong Park,Sean T. Allen,Derrick Hunt,C. Patrick Chaulk,Brian W. Weir +6 more
TL;DR: Having co-morbid conditions was an important correlate of PrEP interest, and PWID who were eligible for PrEP are more likely to be interested in taking it.
Journal ArticleDOI
The Pre-exposure Prophylaxis (PrEP) Care Cascade in People Who Inject Drugs: A Systematic Review
TL;DR: It is suggested that more efforts are needed to identify and screen people who inject drugs for PrEP eligibility and to link and maintain them with appropriate PrEP care, as well as to provide insight into practice and public policy on efficacious strategies to reduce HIV incidence.
Journal ArticleDOI
Barriers and Facilitators to PrEP Use Among People Who Inject Drugs in Rural Appalachia: A Qualitative Study.
Sean T. Allen,Allison O’Rourke,Rebecca Hamilton White,Katherine Clegg Smith,Brian W. Weir,Gregory M. Lucas,Susan G. Sherman,Suzanne M. Grieb +7 more
TL;DR: Qualitative interviews with PWID in two rural counties in West Virginia provided important insights into the barriers and facilitators of PrEP utilization among rural PWID.
Journal ArticleDOI
The PrEP Care Continuum Among Cisgender Women Who Sell Sex and/or Use Drugs Globally: A Systematic Review.
Jennifer L. Glick,Rienna Russo,Belinda Jivapong,Lori Rosman,Danielle Pelaez,Katherine H.A. Footer,Susan G. Sherman +6 more
TL;DR: The first systematic review on the pre-exposure prophylaxis (PrEP) continuum among FSW and/or WWUD among cisgender female sex workers is conducted, searching PubMed, Embase, CINAHL, PsycInfo, and Sociological Abstracts.
References
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Journal ArticleDOI
Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
TL;DR: Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects and Detectable blood levels strongly correlated with the prophylactic effect.
Journal ArticleDOI
Respondent-driven sampling : A new approach to the study of hidden populations
TL;DR: A new variant of chain-referral sampling, respondent-driven sampling, is introduced that employs a dual system of structured incentives to overcome some of the deficiencies of such samples and discusses how respondent- driven sampling can improve both network sampling and ethnographic investigation.
Journal ArticleDOI
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more
TL;DR: Oral TDF and TDF-FTC both protect against HIV-1 infection in heterosexual men and women, and both study medications significantly reduced the HIV- 1 incidence among both men andWomen.
Journal ArticleDOI
Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.
Michael C. Thigpen,Poloko Kebaabetswe,Lynn A. Paxton,Dawn K. Smith,Charles E. Rose,Tebogo M. Segolodi,Faith L. Henderson,Sonal R Pathak,Fatma A. Soud,Kata Chillag,Rodreck Mutanhaurwa,Lovemore Ian Chirwa,Michael Kasonde,Daniel Abebe,Evans Buliva,Roman Gvetadze,Sandra H. Johnson,Thom Sukalac,Vasavi Thomas,Clyde E. Hart,Jeffrey A. Johnson,C. Kevin Malotte,Craig W. Hendrix,John T. Brooks +23 more
TL;DR: Daily TDF-FTC prophylaxis prevented HIV infection in sexually active heterosexual adults and had a significant decline in bone mineral density, which remains unknown.
Journal ArticleDOI
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial
Kachit Choopanya,Michael Martin,Michael Martin,Pravan Suntharasamai,Udomsak Sangkum,Philip A. Mock,Manoj Leethochawalit,Sithisat Chiamwongpaet,Praphan Kitisin,Pitinan Natrujirote,Somyot Kittimunkong,Rutt Chuachoowong,Roman Gvetadze,Janet M. McNicholl,Janet M. McNicholl,Lynn A. Paxton,Marcel E. Curlin,Marcel E. Curlin,Craig W. Hendrix,Suphak Vanichseni +19 more
TL;DR: Daily oral tenofovir reduced the risk of HIV infection in people who inject drugs and can now be considered for use as part of an HIV prevention package for people who injecting drugs.
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Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more