Journal ArticleDOI
Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine.
Emmanuel Le Poul,Claudette Boni,Naïma Hanoun,A. M. Laporte,N Laaris,Jacques Chauveau,Michel Hamon,Laurence Lanfumey +7 more
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TLDR
The decrease in 5-HT1A mRNA levels in the anterior raphe suggests that fluoxetine-induced desensitization of 5- HT1A autoreceptors involves changes at the transcription level.About:
This article is published in Neuropharmacology.The article was published on 2000-01-01. It has received 244 citations till now. The article focuses on the topics: Dorsal raphe nucleus & Raphe nuclei.read more
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Altered serotonin 1A binding in major depression : A [carbonyl-c-11]way100635 positron emission tomography study
Ramin V. Parsey,Maria A. Oquendo,R. Todd Ogden,Doreen M. Olvet,Norman R. Simpson,Yung-yu Huang,Ronald L. Van Heertum,Victoria Arango,J. John Mann +8 more
TL;DR: AN have higher 5-HT(1A) than controls and AE suggesting a model of depression characterized by an over expression of autoinhibitory somatodendritic 5- HT( 1A) receptors, perhaps due to the higher expressing G allele, that may result in reduced terminal field 5-ht release.
Journal ArticleDOI
Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders.
TL;DR: The hippocampal neurogenesis response to experimental paradigms of stress and antidepressant treatment is examined, in which neurotrophic factors are considered to play key roles according to the current views on the pathophysiology of depressive disorders.
Journal ArticleDOI
Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter.
V. Fabre,C. Beaufour,Alexis Evrard,A. Rioux,Naïma Hanoun,K.P. Lesch,Dennis L. Murphy,Laurence Lanfumey,Michel Hamon,Marie-Pascale Martres +9 more
TL;DR: Quantification of [35S]GTP‐γ‐S binding evoked by potent 5‐HT1 receptor agonists confirmed changes as a decrease in this parameter was noted in the DRN (−66%) and the substantia nigra (−30%) but not other brain areas in 5‐ HTT–/– vs. 5-HTT+/+ mice.
Journal ArticleDOI
Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor
Darlene Coleman Deecher,Chad E. Beyer,Grace H. Johnston,Jenifer A. Bray,Syd Shah,Magid Abou-Gharbia,Terrance H. Andree +6 more
TL;DR: DVS is a new 5-HT and NE reuptake inhibitor in vitro and in vivo that demonstrates good brain-to-plasma ratios, suggesting utility in a variety of central nervous system-related disorders.
Journal ArticleDOI
Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences.
TL;DR: The density of 5-HT1A receptors in the dorsal raphe was reduced in both male and female 5- HTT −/− mice, suggesting that the desensitization of 4-HT2 receptors in5-HTT − /− mice may be attributable to a reduction in the density of 7-HT 1A receptors.
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
Journal ArticleDOI
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
André Parent,Lili-Naz Hazrati +1 more
TL;DR: The basal ganglia circuitry is designed so as to modulate in a precise manner the neuronal activity of several brain functional systems, which are involved in the direct control of different aspects of psychomotor behavior.
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