Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review.
Peter J. Basser,Derek K. Jones +1 more
TLDR
In this article, the theoretical underpinnings of diffusion-tensor magnetic resonance imaging (DT-MRI), as well as experimental design and data analysis issues are discussed. And new statistical methods have been developed to analyse DT-MRI data, and their potential uses in clinical and multi-site studies.Abstract:
This article treats the theoretical underpinnings of diffusion-tensor magnetic resonance imaging (DT-MRI), as well as experimental design and data analysis issues. We review the mathematical model underlying DT-MRI, discuss the quantitative parameters that are derived from the measured effective diffusion tensor, and describe artifacts that arise in typical DT-MRI acquisitions. We also discuss difficulties in identifying appropriate models to describe water diffusion in heterogeneous tissues, as well as in interpreting experimental data obtained in such issues. Finally, we describe new statistical methods that have been developed to analyse DT-MRI data, and their potential uses in clinical and multi-site studies.read more
Citations
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Journal ArticleDOI
White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI
TL;DR: The physics of DW-MRI is reviewed, currently preferred methodology is indicated, and the limits of interpretation of its results are explained, with a list of 'Do's and Don'ts' which define good practice in this expanding area of imaging neuroscience.
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Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research
TL;DR: Diffusion tensor imaging (DTI) is a recently developed MRI technique that can measure macroscopic axonal organization in nervous system tissues and several applications are introduced, including visualization of axonal tracts in myelin and axonal injuries as well as human brain and mouse embryonic development.
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Looking into the functional architecture of the brain with diffusion MRI
TL;DR: An introduction to the key physical concepts that underlie dMRI is provided, and its potential applications in the neurosciences and associated clinical fields are reviewed.
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Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review
Yaniv Assaf,Ofer Pasternak +1 more
TL;DR: While DTI offers a powerful tool to study and visualize white matter, it suffers from inherent artifacts and limitations and provides an efficient tool for comprehensive, noninvasive, functional anatomy mapping of the human brain.
Journal ArticleDOI
Sex differences in the structural connectome of the human brain.
Madhura Ingalhalikar,Alex J. Smith,Drew Parker,Theodore D. Satterthwaite,Mark A. Elliott,Kosha Ruparel,Hakon Hakonarson,Raquel E. Gur,Ruben C. Gur,Ragini Verma +9 more
TL;DR: Overall, the results suggest that male brains are structured to facilitate connectivity between perception and coordinated action, whereas female brains are designed to facilitate communication between analytical and intuitive processing modes.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
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Spin diffusion measurements : spin echoes in the presence of a time-dependent field gradient
E. O. Stejskal,J. E. Tanner +1 more
TL;DR: In this article, a derivation of the effect of a time-dependent magnetic field gradient on the spin-echo experiment, particularly in the presence of spin diffusion, is given.
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MR diffusion tensor spectroscopy and imaging.
TL;DR: Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff.
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Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
TL;DR: The diagonal and off-diagonal elements of the effective self-diffusion tensor, Deff, are related to the echo intensity in an NMR spin-echo experiment.
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Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging.
TL;DR: It is shown that neuronal pathways in the rat brain can be probed in situ using high‐resolution three‐dimensional diffusion magnetic resonance imaging and a newly designed tracking approach.