Diffusion-weighted imaging in rectal cancer: current applications and future perspectives
Niels W Schurink,Niels W Schurink,Doenja M. J. Lambregts,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan +4 more
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TLDR
Current applications and clinical utility of diffusion-weighted imaging (DWI) for rectal cancer is summarized, and the role of DWI for further clinical tumour and nodal staging is less well-defined, although there could be a benefit for DWI to help detect lymph nodes.Abstract:
This review summarizes current applications and clinical utility of diffusion-weighted imaging (DWI) for rectal cancer and in addition provides a brief overview of more recent developments (including intravoxel incoherent motion imaging, diffusion kurtosis imaging, and novel postprocessing tools) that are still in more early stages of research. More than 140 papers have been published in the last decade, during which period the use of DWI have slowly moved from mainly qualitative (visual) image interpretation to increasingly advanced methods of quantitative analysis. So far, the largest body of evidence exists for assessment of tumour response to neoadjuvant treatment. In this setting, particularly the benefit of DWI for visual assessment of residual tumour in post-radiation fibrosis has been established and is now increasingly adopted in clinics. Quantitative DWI analysis (mainly the apparent diffusion coefficient) has potential, both for response prediction as well as for tumour prognostication, but protocols require standardization and results need to be prospectively confirmed on larger scale. The role of DWI for further clinical tumour and nodal staging is less well-defined, although there could be a benefit for DWI to help detect lymph nodes. Novel methods of DWI analysis and post-processing are still being developed and optimized; the clinical potential of these tools remains to be established in the upcoming years.read more
Citations
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Deep learning-based radiomic features for improving neoadjuvant chemoradiation response prediction in locally advanced rectal cancer.
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Quantitative Magnetic Resonance Imaging for Biological Image-Guided Adaptive Radiotherapy.
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European guideline for imaging in paediatric and adolescent rhabdomyosarcoma - joint statement by the European Paediatric Soft Tissue Sarcoma Study Group, the Cooperative Weichteilsarkom Studiengruppe and the Oncology Task Force of the European Society of Paediatric Radiology
Roelof van Ewijk,Reineke A. Schoot,Monika Sparber-Sauer,Simone A J Ter Horst,Nina Jehanno,Lise Borgwardt,Bart de Keizer,Johannes H. M. Merks,Alberto De Luca,Kieran McHugh,Thekla von Kalle,Jürgen F. Schäfer,Rick R. van Rijn +12 more
TL;DR: The European rhabdomyosarcoma imaging guideline as mentioned in this paper was developed in collaboration between the EpSSG Imaging Committee, the Cooperative Weichteilsarkom Studiengruppe (CWS) Imaging Group, and the Oncology Task Force of the European Society of Paediatric Radiology (ESPR).
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Feasibility and reproducibility of T2 mapping and DWI for identifying malignant lymph nodes in rectal cancer
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References
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Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.
TL;DR: Clinical results showed significant promise of the IVIM method for tissue characterization by perfusion patterns and for functional studies in the evaluation of the microcirculation in physiologic and pathologic conditions, as, for instance, in brain ischemia.
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Diffusional kurtosis imaging: The quantification of non-gaussian water diffusion by means of magnetic resonance imaging
TL;DR: From the study of six healthy adult subjects, the excess diffusional kurtosis is found to be significantly higher in white matter than in gray matter, reflecting the structural differences between these two types of cerebral tissues.
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Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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MRI quantification of non-Gaussian water diffusion by kurtosis analysis.
Jens H. Jensen,Joseph A. Helpern +1 more
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