Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells
Donna Rill,Donna Rill,Victor M. Santana,Victor M. Santana,W. Mark Roberts,W. Mark Roberts,Terri Nilson,Terri Nilson,Laura C. Bowman,Laura C. Bowman,Robert A. Krance,Robert A. Krance,Helen E. Heslop,Helen E. Heslop,Robert C. Moen,Robert C. Moen,James N. Ihle,James N. Ihle,Malcolm K. Brenner +18 more
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TLDR
The marker-gene technique described should permit evaluation of the mechanisms of relapse and the efficacy of purging in patients receiving autologous marrow transplantation for other solid tumors that infiltrate the marrow.About:
This article is published in Blood.The article was published on 1994-07-15 and is currently open access. It has received 401 citations till now. The article focuses on the topics: Bone marrow & Transplantation.read more
Citations
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Journal ArticleDOI
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
TL;DR: There is growing evidence that the production and activity of IL-1, particularly IL- 1 beta, are tightly regulated events as if nature has placed specific "road blocks" to reduce the response toIL-1 during disease.
Journal ArticleDOI
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
TL;DR: The daily turnover in a normal adult of approximately 1012 blood cells is tightly regulated, involving hematopoietic progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting stem cells.
Journal ArticleDOI
Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.
Donald B. Kohn,Kenneth I. Weinberg,Jan A. Nolta,L N Heiss,Carl Lenarsky,Crooks Gm,M E Hanley,G Annett,J. Brooks,A el-Khoureiy +9 more
TL;DR: The continued presence and expression of the introduced gene in leukocytes from bone marrow and peripheral blood for 18 months demonstrates that umbilical cord blood cells may be genetically modified with retroviral vectors and engrafted in neonates for gene therapy.
Journal ArticleDOI
Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation.
Cynthia E. Dunbar,Michele Cottler-Fox,Joyce A. O'Shaughnessy,Sandra Doren,Corey A. Carter,Berenson R,S Brown,Robert C. Moen,J.J. Greenblatt,F. M. Stewart +9 more
TL;DR: It is suggested that mobilized PB cells may be preferable to BM for gene therapy applications and that progeny of mobilized peripheral blood cells can contribute long-term to engraftment of multiple lineages.
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Neuroblastoma
TL;DR: Neuroblastoma is a type of cancer that most often affects children and can spread to other parts of the body such as the bones, liver, or skin.
References
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Journal ArticleDOI
Genetic Applications of an Inverse Polymerase Chain Reaction
TL;DR: The feasibility of IPCR is shown by amplifying the sequences that flank an IS1 element in the genome of a natural isolate of Escherichia coli.
Journal ArticleDOI
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation
Malcolm K. Brenner,Donna Rill,Robert A. Krance,James N. Ihle,Robert C. Moen,Joseph Mirro,William F. Anderson +6 more
TL;DR: Transfer of the neomycin-resistance gene into bone-marrow cells harvested from children with acute myeloid leukaemia in remission should enable the development of better marrow purging strategies.
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A procedure for in vitro amplification of DNA segments that lie outside the boundaries of known sequences
Journal ArticleDOI
Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma.
John G. Gribben,Arnold S. Freedman,Donna Neuberg,Denis-Claude Roy,K Blake,S D Woo,Michael L. Grossbard,SN Rabinowe,F Coral,Gordon J. Freeman +9 more
TL;DR: Evidence is provided of the clinical usefulness of ex vivo purging of autologous bone marrow in the treatment of patients with lymphoma and suggest that the reinfusion of malignant cells in autOLOGous marrow contributes to relapse.
Journal ArticleDOI
Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region.
TL;DR: It is found that retroviral vectors containing the complete packaging signal allow more efficient gene transfer into a variety of cell types and may help explain why many oncogenic retroviruses have retained gag sequences and often express transforming proteins that are gag-onc hybrids.
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