Journal ArticleDOI
Discovering the neural basis of human social anxiety: a diagnostic and therapeutic imperative.
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This article is published in American Journal of Psychiatry.The article was published on 2004-01-01. It has received 1293 citations till now. The article focuses on the topics: Social anxiety.read more
Citations
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Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Jeffrey A. Lieberman,T. Scott Stroup,Joseph P. McEvoy,Joseph P. McEvoy,Marvin S. Swartz,Robert A. Rosenheck,Diana O. Perkins,Richard S.E. Keefe,Sonia M. Davis,C.E. Davis,Barry D. Lebowitz,Joanne B. Severe,John K. Hsiao +12 more
TL;DR: Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone.
Journal ArticleDOI
Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
Stefan Leucht,Caroline Corves,Caroline Corves,Dieter Arbter,Rolf R. Engel,Chunbo Li,Chunbo Li,John M. Davis +7 more
TL;DR: A meta-analysis of randomised controlled trials to compare the effects of second-generation antipsychotic drugs in patients with schizophrenia provided data for individualised treatment based on efficacy, side-effects, and cost.
Journal ArticleDOI
Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert.
Mohammed R. Milad,Christopher I. Wright,Christopher I. Wright,Scott P. Orr,Scott P. Orr,Roger K. Pitman,Gregory J. Quirk,Scott L. Rauch +7 more
TL;DR: Results support the involvement of the human hippocampus as well as vmPFC in the recall of extinction memory and provide a paradigm for future investigations of fronto-temporal function during extinction recall in psychiatric disorders such as posttraumatic stress disorder.
Journal ArticleDOI
Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
TL;DR: A brief review and critique of the current therapeutic armamentarium for treating schizophrenia and drug development strategies and theories of mechanisms of action of antipsychotic drugs is provided, and focuses on novel targets for therapeutic agents for future drug development.
Journal ArticleDOI
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
TL;DR: The metabolic and cardiovascular risks of various antipsychotic medications in adults and children are outlined, the disparities in health care are defined, and recommendations for screening and monitoring of patients taking these agents are made.
References
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The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Doreen S. Koretz,Kathleen R. Merikangas,A. John Rush,Ellen E. Walters,Philip S. Wang +8 more
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
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Does Rejection Hurt? An fMRI Study of Social Exclusion
Naomi I. Eisenberger,Naomi I. Eisenberger,Matthew D. Lieberman,Matthew D. Lieberman,Kipling D. Williams,Kipling D. Williams +5 more
TL;DR: A neuroimaging study examined the neural correlates of social exclusion and tested the hypothesis that the brain bases of social pain are similar to those of physical pain, suggesting that RVPFC regulates the distress of socialclusion by disrupting ACC activity.
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The neurobiology of attachment
Thomas R. Insel,Larry J. Young +1 more
TL;DR: Over the past decade, studies in a range of vertebrates, including humans, have begun to address the neural basis of attachment at a molecular, cellular and systems level.
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Adolescent social anxiety as an outcome of inhibited temperament in childhood.
TL;DR: The interview and observational data indicate that important aspects of an inhibited temperament are preserved from the second year of life to early adolescence, which predispose an adolescent to social anxiety.
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Increased amygdala activation to angry and contemptuous faces in generalized social phobia.
TL;DR: The pronounced response to contemptuous and angry facial expressions suggests that the amygdala in GSP may be particularly active in the processing of disorder-salient stimuli.
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