Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network.
Fei Zhou,Yimin Wang,Yingmei Liu,Xuedong Liu,Li Gu,Xiaoju Zhang,Zeng-Hui Pu,Guoru Yang,Bo Liu,Qingrong Nie,Bing Xue,Jing Feng,Qiang Guo,Jian-hua Liu,Hong Fan,Jin Chen,Y. Zhang,Zhenyang Xu,Min Pang,Yu Chen,Xiu-Hong Nie,Zhigang Cai,Jin-Fu Xu,Kun Peng,Xiangxin Li,Pingchao Xiang,Z Y Zhang,Shujuan Jiang,Xin Su,Jie Zhang,Yanming Li,Xiuhong Jin,Rongmeng Jiang,Jian-Ping Dong,Yuanlin Song,Hong Zhou,Chen Wang,Bin Cao +37 more
TLDR
The high incidence of complications in non- influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-Influenza virus.Abstract:
Although broad knowledge of influenza viral pneumonia has been established, the significance of non-influenza respiratory viruses in community-acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in the non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals in mainland China. Respiratory viruses were detected by molecular methods. Comparisons were conducted between influenza and non-influenza viral infection groups. In total, 915 out of 2336 adult patients with viral infection were enrolled in the analysis, with influenza virus (28.4%) the most frequently detected virus, followed by respiratory syncytial virus (3.6%), adenovirus (3.3%), human coronavirus (3.0%), parainfluenza virus (2.2%), human rhinovirus (1.8%) and human metapneumovirus (1.5%). Non-influenza viral infections accounted for 27.4% of viral pneumonia. Consolidation was more frequently observed in patients with adenovirus infection. The occurrence of complications such as sepsis (40.1% versus 39.6%; p=0.890) and hypoxaemia (40.1% versus 37.2%; p=0.449) during hospitalisation in the influenza viral infection group did not differ from that of the non-influenza viral infection group. Compared with influenza virus infection, the multivariable adjusted odds ratios of CURB-65 (confusion, urea >7 mmol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza respiratory viruses.read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
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Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score.
TL;DR: An easy-to-use clinically predictive tool for assessing 90-day mortality risk of viral pneumonia that can accurately stratify hospitalized patients with viral pneumonia into relevant risk categories and could provide guidance to make further clinical decisions is designed.
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Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019-a multi-centre observational study.
Yuan Cen,Xian Chen,Ye Shen,Xiaohua Zhang,Yu Lei,Cheng Xu,Wen-Rui Jiang,Hai-Tao Xu,Yang Chen,Jie Zhu,Li-Li Zhang,Yu-Hui Liu +11 more
TL;DR: A panel of risk factors for disease progression in mild to moderate cases with COVID-19 was identified and history of smoking was protective against disease progression.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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Seema Jain,Derek J. Williams,Sandra R. Arnold,Krow Ampofo,Anna M. Bramley,Carrie Reed,Chris Stockmann,Evan J. Anderson,Carlos G. Grijalva,Wesley H. Self,Yuwei Zhu,Anami Patel,Weston Hymas,James D. Chappell,Robert A. Kaufman,J. Herman Kan,David Dansie,Noel Lenny,David R. Hillyard,Lia M. Haynes,Min Z. Levine,Stephen Lindstrom,Jonas M. Winchell,Jacqueline M. Katz,Dean D. Erdman,Eileen Schneider,Lauri A. Hicks,Richard G. Wunderink,Kathryn M. Edwards,Andrew T. Pavia,Jonathan A. McCullers,Lyn Finelli +31 more
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Journal ArticleDOI
BTS guidelines for the management of community acquired pneumonia in adults: update 2009.
Wei Shen Lim,S V Baudouin,R C George,Adam T. Hill,C Jamieson,I Le Jeune,John Macfarlane,Robert C. Read,H J Roberts,Mark L Levy,M Wani,Mark Woodhead +11 more
TL;DR: A summary of the initial management of patients admitted to hospital with suspected community acquired pneumonia (CAP) is presented and the relevant microbiological investigations and empirical antibiotic choices recommended in patients with CAP are summarized.
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