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Journal ArticleDOI

Distance Regularized Level Set Evolution and Its Application to Image Segmentation

TLDR
A new variational level set formulation in which the regularity of the level set function is intrinsically maintained during thelevel set evolution called distance regularized level set evolution (DRLSE), which eliminates the need for reinitialization and thereby avoids its induced numerical errors.
Abstract
Level set methods have been widely used in image processing and computer vision. In conventional level set formulations, the level set function typically develops irregularities during its evolution, which may cause numerical errors and eventually destroy the stability of the evolution. Therefore, a numerical remedy, called reinitialization, is typically applied to periodically replace the degraded level set function with a signed distance function. However, the practice of reinitialization not only raises serious problems as when and how it should be performed, but also affects numerical accuracy in an undesirable way. This paper proposes a new variational level set formulation in which the regularity of the level set function is intrinsically maintained during the level set evolution. The level set evolution is derived as the gradient flow that minimizes an energy functional with a distance regularization term and an external energy that drives the motion of the zero level set toward desired locations. The distance regularization term is defined with a potential function such that the derived level set evolution has a unique forward-and-backward (FAB) diffusion effect, which is able to maintain a desired shape of the level set function, particularly a signed distance profile near the zero level set. This yields a new type of level set evolution called distance regularized level set evolution (DRLSE). The distance regularization effect eliminates the need for reinitialization and thereby avoids its induced numerical errors. In contrast to complicated implementations of conventional level set formulations, a simpler and more efficient finite difference scheme can be used to implement the DRLSE formulation. DRLSE also allows the use of more general and efficient initialization of the level set function. In its numerical implementation, relatively large time steps can be used in the finite difference scheme to reduce the number of iterations, while ensuring sufficient numerical accuracy. To demonstrate the effectiveness of the DRLSE formulation, we apply it to an edge-based active contour model for image segmentation, and provide a simple narrowband implementation to greatly reduce computational cost.

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Citations
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Journal ArticleDOI

A Level Set Method for Image Segmentation in the Presence of Intensity Inhomogeneities With Application to MRI

TL;DR: A novel region-based method for image segmentation, which is able to simultaneously segment the image and estimate the bias field, and the estimated bias field can be used for intensity inhomogeneity correction (or bias correction).
Journal ArticleDOI

Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans

TL;DR: The experimental results show the significant performance boost by the SDAE-based CADx algorithm over the two conventional methods, suggesting that deep learning techniques can potentially change the design paradigm of the CADx systems without the need of explicit design and selection of problem-oriented features.
Proceedings ArticleDOI

Remote Heart Rate Measurement from Face Videos under Realistic Situations

TL;DR: A framework which utilizes face tracking and Normalized Least Mean Square adaptive filtering methods to counter their influences is proposed and it is demonstrated that this method substantially outperforms all previous methods.
Journal ArticleDOI

Robust Nucleus/Cell Detection and Segmentation in Digital Pathology and Microscopy Images: A Comprehensive Review

TL;DR: A comprehensive summary of the recent state-of-the-art nucleus/cell segmentation approaches on different types of microscopy images including bright-field, phase-contrast, differential interference contrast, fluorescence, and electron microscopies is provided.
Journal ArticleDOI

Active contours driven by local and global intensity fitting energy with application to brain MR image segmentation.

TL;DR: An improved region-based active contour model in a variational level set formulation that has been applied to brain MR image segmentation with desirable results and is presented as a two-phaselevel set formulation and then extended to a multi-phase formulation.
References
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Book

Partial Differential Equations

TL;DR: In this paper, the authors present a theory for linear PDEs: Sobolev spaces Second-order elliptic equations Linear evolution equations, Hamilton-Jacobi equations and systems of conservation laws.
Journal ArticleDOI

Snakes : Active Contour Models

TL;DR: This work uses snakes for interactive interpretation, in which user-imposed constraint forces guide the snake near features of interest, and uses scale-space continuation to enlarge the capture region surrounding a feature.
Journal ArticleDOI

Fronts propagating with curvature-dependent speed: algorithms based on Hamilton-Jacobi formulations

TL;DR: The PSC algorithm as mentioned in this paper approximates the Hamilton-Jacobi equations with parabolic right-hand-sides by using techniques from the hyperbolic conservation laws, which can be used also for more general surface motion problems.
Journal ArticleDOI

Active contours without edges

TL;DR: A new model for active contours to detect objects in a given image, based on techniques of curve evolution, Mumford-Shah (1989) functional for segmentation and level sets is proposed, which can detect objects whose boundaries are not necessarily defined by the gradient.
Journal ArticleDOI

Geodesic active contours

TL;DR: A novel scheme for the detection of object boundaries based on active contours evolving in time according to intrinsic geometric measures of the image, allowing stable boundary detection when their gradients suffer from large variations, including gaps.
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