Citations
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Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.
Steven Boeynaems,Alex S. Holehouse,Venera Weinhardt,Venera Weinhardt,Denes Kovacs,Joris Van Lindt,Carolyn A. Larabell,Carolyn A. Larabell,Ludo Van Den Bosch,Ludo Van Den Bosch,Rhiju Das,Peter Tompa,Peter Tompa,Rohit V. Pappu,Aaron D. Gitler +14 more
TL;DR: In this article, the collective interactions among the simplest, biologically relevant proteins and archetypal RNA molecules are sufficient for driving the spontaneous emergence of multilayered condensates with distinct material properties.
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Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
TL;DR: This review addresses the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.
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Diverse and robust molecular algorithms using reprogrammable DNA self-assembly
Damien Woods,Damien Woods,Damien Woods,David Doty,David Doty,Cameron Myhrvold,Cameron Myhrvold,Joy Hui,Joy Hui,Felix Zhou,Felix Zhou,Peng Yin,Peng Yin,Erik Winfree +13 more
TL;DR: A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.
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At the Crossroads of Chemistry, Biology, and Materials: Structural DNA Nanotechnology
TL;DR: The organizational capabilities of structural DNA nanotechnology are just beginning to be explored, and the field is expected ultimately to be able to organize a variety of species that will lead to exciting and possibly revolutionary materials.
Journal ArticleDOI
Materials science of DNA
TL;DR: In this article, the emerging field of DNA materials science, which is expected to add a new horizon to the conventional materials science landscape, is reviewed, and a short overview on recent developments in the non-biological application of DNA and DNA science is provided.
References
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Journal ArticleDOI
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
James D. Watson,Francis Crick +1 more
TL;DR: The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography and opened the way for a deeper understanding of perhaps the most important biological process.
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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
Craig Tuerk,Larry Gold +1 more
TL;DR: High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species.
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In vitro selection of RNA molecules that bind specific ligands.
TL;DR: Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules.
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A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
Journal ArticleDOI
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.